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RRM2 ribonucleotide reductase regulatory subunit M2 [ Homo sapiens (human) ]

Gene ID: 6241, updated on 20-Apr-2020

Summary

Official Symbol
RRM2provided by HGNC
Official Full Name
ribonucleotide reductase regulatory subunit M2provided by HGNC
Primary source
HGNC:HGNC:10452
See related
Ensembl:ENSG00000171848 MIM:180390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R2; RR2; RR2M; C2orf48
Summary
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Expression
Biased expression in bone marrow (RPKM 28.1), lymph node (RPKM 20.5) and 13 other tissues See more
Orthologs

Genomic context

See RRM2 in Genome Data Viewer
Location:
2p25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (10122568..10211010)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10262695..10271546)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Kruppel like factor 11 Neighboring gene cystin 1 Neighboring gene uncharacterized LOC105373424 Neighboring gene microRNA 4261 Neighboring gene uncharacterized LOC101929691 Neighboring gene RNA, 7SL, cytoplasmic 66, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr2.403

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with ribonucleotide reductase M2 (RRM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25102, MGC121034, MGC121036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ferric iron binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein heterotetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
ribonucleoside-diphosphate reductase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase subunit M2
Names
ribonucleotide reductase M2 polypeptide
ribonucleotide reductase small chain
ribonucleotide reductase small subunit
uncharacterized protein C2orf48
NP_001025.1
NP_001159403.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034.4NP_001025.1  ribonucleoside-diphosphate reductase subunit M2 isoform 2

    See identical proteins and their annotated locations for NP_001025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104794, AC118058, BM994533, X59618
    Consensus CDS
    CCDS1669.1
    UniProtKB/Swiss-Prot
    P31350
    Related
    ENSP00000302955.4, ENST00000304567.10
    Conserved Domains (1) summary
    PLN02492
    Location:70389
    PLN02492; ribonucleoside-diphosphate reductase
  2. NM_001165931.1NP_001159403.1  ribonucleoside-diphosphate reductase subunit M2 isoform 1

    See identical proteins and their annotated locations for NP_001159403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104794, AC118058, BM994533, DA477511, X59618
    Consensus CDS
    CCDS54334.1
    UniProtKB/Swiss-Prot
    P31350
    Related
    ENSP00000484183.1, ENST00000615152.4
    Conserved Domains (1) summary
    PLN02492
    Location:130449
    PLN02492; ribonucleoside-diphosphate reductase

RNA

  1. NR_164157.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007240, AC104794

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    10122568..10211010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_161344.1: Suppressed sequence

    Description
    NR_161344.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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