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ZNF385C zinc finger protein 385C [ Homo sapiens (human) ]

Gene ID: 201181, updated on 23-Nov-2023

Summary

Official Symbol
ZNF385Cprovided by HGNC
Official Full Name
zinc finger protein 385Cprovided by HGNC
Primary source
HGNC:HGNC:33722
See related
Ensembl:ENSG00000187595 AllianceGenome:HGNC:33722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 4.2), testis (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF385C in Genome Data Viewer
Location:
17q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42025576..42098473, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42882106..42954978, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40177594..40250491, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40085993-40086896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40091696-40092276 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:40102816-40102967 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40110957-40111564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40111565-40112170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112171-40112776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112777-40113382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40119287-40119844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40119845-40120402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40120403-40120960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40139962-40140462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40140463-40140963 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:40162959-40163488 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40180775-40181563 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene chromosome 17 open reading frame 113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40203397-40203898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40214064-40214654 Neighboring gene Sharpr-MPRA regulatory region 8946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8513 Neighboring gene Sharpr-MPRA regulatory region 13373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40220039-40220539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40223445-40224418 Neighboring gene Sharpr-MPRA regulatory region 2167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40256421-40257354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40257355-40258286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40259930-40260442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40267799-40268334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8516 Neighboring gene DExH-box helicase 58 Neighboring gene lysine acetyltransferase 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 385C
Names
CTD-2132N18.2
CTD-2132N18.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378270.1NP_001365199.1  zinc finger protein 385C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:4574
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:303371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:370394
    zf-met; Zinc-finger of C2H2 type
  2. NM_001392013.1NP_001378942.1  zinc finger protein 385C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105024
    Consensus CDS
    CCDS92306.1
    UniProtKB/TrEMBL
    A0A8I5KWL9, C9J6X6
    Related
    ENSP00000509658.1, ENST00000692273.1
    Conserved Domains (3) summary
    smart00451
    Location:4574
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371395
    zf-met; Zinc-finger of C2H2 type
  3. NM_001392014.1NP_001378943.1  zinc finger protein 385C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:4574
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:302370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:369393
    zf-met; Zinc-finger of C2H2 type
  4. NM_001392015.1NP_001378944.1  zinc finger protein 385C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:4574
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371395
    zf-met; Zinc-finger of C2H2 type
  5. NM_001392016.1NP_001378945.1  zinc finger protein 385C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:4574
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371395
    zf-met; Zinc-finger of C2H2 type
  6. NM_001392017.1NP_001378946.1  zinc finger protein 385C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (2) summary
    sd00020
    Location:230298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:297321
    zf-met; Zinc-finger of C2H2 type
  7. NM_001392018.1NP_001378947.1  zinc finger protein 385C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/Swiss-Prot
    A0A087WX54, Q4G0J1, Q66K41
    Related
    ENSP00000497755.1, ENST00000649819.1
    Conserved Domains (2) summary
    sd00020
    Location:225293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:292316
    zf-met; Zinc-finger of C2H2 type
  8. NM_001393562.1NP_001380491.1  zinc finger protein 385C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Related
    ENSP00000411514.4, ENST00000436535.5
    Conserved Domains (2) summary
    smart00451
    Location:160187
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:305373
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42025576..42098473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42882106..42954978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013624.2: Suppressed sequence

    Description
    NM_001013624.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001242704.1: Suppressed sequence

    Description
    NM_001242704.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.