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ZNF385C zinc finger protein 385C [ Homo sapiens (human) ]

Gene ID: 201181, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF385Cprovided by HGNC
Official Full Name
zinc finger protein 385Cprovided by HGNC
Primary source
HGNC:HGNC:33722
See related
Ensembl:ENSG00000187595 MIM:620982; AllianceGenome:HGNC:33722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 4.2), testis (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF385C in Genome Data Viewer
Location:
17q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42025576..42098473, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42882106..42954978, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40177594..40250491, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40085993-40086896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40091696-40092276 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:40102816-40102967 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40110957-40111564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40111565-40112170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112171-40112776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112777-40113382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40119287-40119844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40119845-40120402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40120403-40120960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40139962-40140462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40140463-40140963 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:40162959-40163488 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40180775-40181563 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene chromosome 17 open reading frame 113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40203397-40203898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40214064-40214654 Neighboring gene Sharpr-MPRA regulatory region 8946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8513 Neighboring gene Sharpr-MPRA regulatory region 13373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40220039-40220539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40223445-40224418 Neighboring gene Sharpr-MPRA regulatory region 2167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40256421-40257354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40257355-40258286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40259930-40260442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40267799-40268334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8516 Neighboring gene DExH-box helicase 58 Neighboring gene lysine acetyltransferase 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  2. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 385C
Names
CTD-2132N18.2
CTD-2132N18.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378270.1 → NP_001365199.1  zinc finger protein 385C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:45 → 74
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:303 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:370 → 394
    zf-met; Zinc-finger of C2H2 type

  2. NM_001392013.1 → NP_001378942.1  zinc finger protein 385C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105024
    Consensus CDS
    CCDS92306.1
    UniProtKB/TrEMBL
    A0A8I5KWL9, C9J6X6
    Related
    ENSP00000509658.1, ENST00000692273.1
    Conserved Domains (3) summary
    smart00451
    Location:45 → 74
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371 → 395
    zf-met; Zinc-finger of C2H2 type

  3. NM_001392014.1 → NP_001378943.1  zinc finger protein 385C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:45 → 74
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:302 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:369 → 393
    zf-met; Zinc-finger of C2H2 type

  4. NM_001392015.1 → NP_001378944.1  zinc finger protein 385C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:45 → 74
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371 → 395
    zf-met; Zinc-finger of C2H2 type

  5. NM_001392016.1 → NP_001378945.1  zinc finger protein 385C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (3) summary
    smart00451
    Location:45 → 74
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:304 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:371 → 395
    zf-met; Zinc-finger of C2H2 type

  6. NM_001392017.1 → NP_001378946.1  zinc finger protein 385C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Conserved Domains (2) summary
    sd00020
    Location:230 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:297 → 321
    zf-met; Zinc-finger of C2H2 type

  7. NM_001392018.1 → NP_001378947.1  zinc finger protein 385C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/Swiss-Prot
    A0A087WX54, Q4G0J1, Q66K41
    Related
    ENSP00000497755.1, ENST00000649819.1
    Conserved Domains (2) summary
    sd00020
    Location:225 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:292 → 316
    zf-met; Zinc-finger of C2H2 type

  8. NM_001393562.1 → NP_001380491.1  zinc finger protein 385C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC105024
    UniProtKB/TrEMBL
    C9J6X6
    Related
    ENSP00000411514.4, ENST00000436535.5
    Conserved Domains (2) summary
    smart00451
    Location:160 → 187
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:305 → 373
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42025576..42098473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42882106..42954978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013624.2: Suppressed sequence

    Description
    NM_001013624.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001242704.1: Suppressed sequence

    Description
    NM_001242704.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66K41.4 GenPept UniProtKB/Swiss-Prot:Q66K41

Gene LinkOut

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