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Sub1 SUB1 homolog, transcriptional regulator [ Mus musculus (house mouse) ]

Gene ID: 20024, updated on 21-Apr-2024

Summary

Official Symbol
Sub1provided by MGI
Official Full Name
SUB1 homolog, transcriptional regulatorprovided by MGI
Primary source
MGI:MGI:104811
See related
Ensembl:ENSMUSG00000022205 AllianceGenome:MGI:104811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P9; P15; Pc4; Rpo2tc1
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within SMAD protein signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 13 other tissues See more
Orthologs
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Genomic context

Location:
15 A1; 15 5.9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11981422..11996091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11981336..11996038, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34618 Neighboring gene RIKEN cDNA 1700047G03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7360 Neighboring gene SEC13 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8584 Neighboring gene STARR-positive B cell enhancer ABC_E3132 Neighboring gene STARR-positive B cell enhancer ABC_E7361 Neighboring gene STARR-seq mESC enhancer starr_38007 Neighboring gene predicted gene 2559 Neighboring gene predicted gene, 34759

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
activated RNA polymerase II transcriptional coactivator p15
Names
RNA polymerase II transcriptional coactivator
p14
positive cofactor 4
single-stranded DNA-binding protein p9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411715.1NP_001398644.1  activated RNA polymerase II transcriptional coactivator p15

    Status: VALIDATED

    Source sequence(s)
    AC121860
    UniProtKB/Swiss-Prot
    P11031, Q3UJR5, Q543N2
  2. NM_011294.4NP_035424.1  activated RNA polymerase II transcriptional coactivator p15

    See identical proteins and their annotated locations for NP_035424.1

    Status: VALIDATED

    Source sequence(s)
    AC121860
    Consensus CDS
    CCDS27387.1
    UniProtKB/Swiss-Prot
    P11031, Q3UJR5, Q543N2
    Related
    ENSMUSP00000022816.9, ENSMUST00000022816.15
    Conserved Domains (1) summary
    pfam02229
    Location:68115
    PC4; Transcriptional Coactivator p15 (PC4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    11981422..11996091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)