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SUB1 SUB1 homolog, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 10923, updated on 6-Jan-2019

Summary

Official Symbol
SUB1provided by HGNC
Official Full Name
SUB1 homolog, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:19985
See related
Ensembl:ENSG00000113387 MIM:600503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P15; PC4; p14
Expression
Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues See more
Orthologs

Genomic context

See SUB1 in Genome Data Viewer
Location:
5p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (32531778..32604079)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32585605..32604185)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger RNA binding protein Neighboring gene microRNA 579 Neighboring gene transmembrane protein 183A pseudogene Neighboring gene long intergenic non-protein coding RNA 2061 Neighboring gene natriuretic peptide receptor 3 Neighboring gene NPR3 intron CAGE-defined low expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SUB1 PubMed
Knockdown of SUB1 homolog by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, SUB1 homolog (positive cofactor 4), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Through amino acids 22-91, PC4 binds to the basic TAR binding domain of HIV-1 Tat (amino acids 49-57) and enhances activation of the HIV-1 LTR promoter in a Tat dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102747

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activated RNA polymerase II transcriptional coactivator p15
Names
activated RNA polymerase II transcription cofactor 4
positive cofactor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006713.4NP_006704.3  activated RNA polymerase II transcriptional coactivator p15

    See identical proteins and their annotated locations for NP_006704.3

    Status: VALIDATED

    Source sequence(s)
    AC074134, BC010537, BC071655, BX472106
    Consensus CDS
    CCDS3897.1
    UniProtKB/Swiss-Prot
    P53999
    UniProtKB/TrEMBL
    Q6IBA2
    Related
    ENSP00000265073.4, ENST00000265073.8
    Conserved Domains (1) summary
    pfam02229
    Location:68115
    PC4; Transcriptional Coactivator p15 (PC4)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    32531778..32604079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008986.1XP_016864475.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    P53999
    UniProtKB/TrEMBL
    Q6IBA2
    Related
    ENSP00000422806.1, ENST00000512913.5
    Conserved Domains (1) summary
    pfam02229
    Location:68115
    PC4; Transcriptional Coactivator p15 (PC4)
  2. XM_017008987.1XP_016864476.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    P53999
    UniProtKB/TrEMBL
    Q6IBA2
    Conserved Domains (1) summary
    pfam02229
    Location:68115
    PC4; Transcriptional Coactivator p15 (PC4)
  3. XM_011513944.3XP_011512246.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    See identical proteins and their annotated locations for XP_011512246.1

    UniProtKB/Swiss-Prot
    P53999
    UniProtKB/TrEMBL
    Q6IBA2
    Conserved Domains (1) summary
    pfam02229
    Location:68115
    PC4; Transcriptional Coactivator p15 (PC4)
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