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Polr2j polymerase (RNA) II (DNA directed) polypeptide J [ Mus musculus (house mouse) ]

Gene ID: 20022, updated on 11-Apr-2024

Summary

Official Symbol
Polr2jprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Jprovided by MGI
Primary source
MGI:MGI:109582
See related
Ensembl:ENSMUSG00000039771 AllianceGenome:MGI:109582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Polr2i; Rpb11a; Rpo2-4; 14.5kDa
Summary
Predicted to enable LRR domain binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; branchial arch; integumental system; limb; and nervous system. Orthologous to several human genes including POLR2J (RNA polymerase II subunit J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 53.1), liver E14 (RPKM 50.1) and 28 other tissues See more
Orthologs
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Genomic context

See Polr2j in Genome Data Viewer
Location:
5 G2; 5 75.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136145545..136151801)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136116691..136122947)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene RAS p21 protein activator 4 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6388 Neighboring gene alkB homolog 4, lysine demethylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase II subunit RPB11
Names
DNA-directed RNA polymerase II 13.3 kDa polypeptide
DNA-directed RNA polymerase II subunit J
RNA polymerase II 13.3 kDa subunit
RNA polymerase II 4 (14 kDa subunit)
RNA polymerase II subunit B11
RNA polymerase II subunit RPB14
RPB14
polymerase (RNA) II (DNA directed) polypeptide I
NP_035423.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011293.2NP_035423.2  DNA-directed RNA polymerase II subunit RPB11

    See identical proteins and their annotated locations for NP_035423.2

    Status: VALIDATED

    Source sequence(s)
    AK158610, DV065741
    Consensus CDS
    CCDS19751.1
    UniProtKB/Swiss-Prot
    O08740
    UniProtKB/TrEMBL
    Q3TYI2, Q6PI63
    Related
    ENSMUSP00000038505.8, ENSMUST00000041366.14
    Conserved Domains (1) summary
    cd06926
    Location:14105
    RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136145545..136151801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)