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POLR2J RNA polymerase II subunit J [ Homo sapiens (human) ]

Gene ID: 5439, updated on 8-Jul-2018
Official Symbol
POLR2Jprovided by HGNC
Official Full Name
RNA polymerase II subunit Jprovided by HGNC
Primary source
HGNC:HGNC:9197
See related
Ensembl:ENSG00000005075 MIM:604150; Vega:OTTHUMG00000150387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPB11; RPB11A; RPB11m; hRPB14; POLR2J1
Summary
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 20.7), fat (RPKM 18.2) and 25 other tissues See more
Orthologs
See POLR2J in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (102473100..102478934, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102113547..102119446, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 5090 Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RAS p21 protein activator 4B Neighboring gene uroplakin 3B like 2 Neighboring gene RNA polymerase II subunit J3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) II (DNA directed) polypeptide J (POLR2J, 13.3kDa) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC71910

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
CONTRIBUTES_TO DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed 5'-3' RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
LRR domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
CONTRIBUTES_TO RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-directed RNA polymerase II subunit RPB11-a
Names
DNA-directed RNA polymerase II subunit J-1
RNA polymerase II 13.3 kDa subunit
RNA polymerase II subunit B11-a
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
polymerase (RNA) II subunit J
NP_006225.1
XP_005250509.1
XP_016867842.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006234.4NP_006225.1  DNA-directed RNA polymerase II subunit RPB11-a

    See identical proteins and their annotated locations for NP_006225.1

    Status: REVIEWED

    Source sequence(s)
    BC065711, BM545237, BM791979
    Consensus CDS
    CCDS5724.1
    UniProtKB/Swiss-Prot
    P52435
    Related
    ENSP00000292614.5, OTTHUMP00000197252, ENST00000292614.9, OTTHUMT00000317913
    Conserved Domains (1) summary
    cd06926
    Location:14105
    RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    102473100..102478934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012353.1XP_016867842.1  DNA-directed RNA polymerase II subunit RPB11-a isoform X2

  2. XM_005250452.5XP_005250509.1  DNA-directed RNA polymerase II subunit RPB11-a isoform X1

    Related
    ENSP00000377383.4, ENST00000393794.4
    Conserved Domains (2) summary
    cd06926
    Location:14105
    RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II
    pfam01193
    Location:3398
    RNA_pol_L; RNA polymerase Rpb3/Rpb11 dimerization domain
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