U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polr2c polymerase (RNA) II (DNA directed) polypeptide C [ Mus musculus (house mouse) ]

Gene ID: 20021, updated on 8-Feb-2024

Summary

Official Symbol
Polr2cprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Cprovided by MGI
Primary source
MGI:MGI:109299
See related
Ensembl:ENSMUSG00000031783 AllianceGenome:MGI:109299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPB3; 33kDa; Rpo2-3; mRBP31
Summary
Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in 1st branchial arch; alimentary system; limb; and sensory organ. Orthologous to human POLR2C (RNA polymerase II subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 36.8), CNS E14 (RPKM 33.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Polr2c in Genome Data Viewer
Location:
8 C5; 8 46.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95584078..95590870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94857450..94864242)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene coenzyme Q9 Neighboring gene STARR-positive B cell enhancer ABC_E10518 Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118242

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase II subunit RPB3
Names
DNA-directed RNA polymerase II 33 kDa polypeptide
DNA-directed RNA polymerase II subunit C
RNA polymerase II 3
RNA polymerase II subunit 3
RNA polymerase II subunit B3
RPB31
RPB33
NP_033116.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009090.5NP_033116.2  DNA-directed RNA polymerase II subunit RPB3

    See identical proteins and their annotated locations for NP_033116.2

    Status: VALIDATED

    Source sequence(s)
    AC129606
    Consensus CDS
    CCDS40442.1
    UniProtKB/Swiss-Prot
    P97760, Q99M46
    UniProtKB/TrEMBL
    Q9DB22
    Related
    ENSMUSP00000105147.4, ENSMUST00000109521.4
    Conserved Domains (1) summary
    cd07031
    Location:7266
    RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95584078..95590870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)