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POLR2C RNA polymerase II subunit C [ Homo sapiens (human) ]

Gene ID: 5432, updated on 3-May-2020


Official Symbol
POLR2Cprovided by HGNC
Official Full Name
RNA polymerase II subunit Cprovided by HGNC
Primary source
See related
Ensembl:ENSG00000102978 MIM:180663
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPB3; RPB31; hRPB33; hsRPB3
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
Ubiquitous expression in thyroid (RPKM 43.5), adrenal (RPKM 39.1) and 25 other tissues See more

Genomic context

See POLR2C in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57462679..57472009)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57496551..57505921)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 17 Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene coenzyme Q9 Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene adhesion G protein-coupled receptor G5 Neighboring gene uncharacterized LOC105371291 Neighboring gene uncharacterized LOC107984889

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) II (DNA directed) polypeptide C (POLR2C, 33kDa) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
protein binding IPI
Inferred from Physical Interaction
more info
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
cytosol IDA
Inferred from Direct Assay
more info
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
nucleoplasm IDA
Inferred from Direct Assay
more info
nucleoplasm TAS
Traceable Author Statement
more info
nucleus IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerase II 33 kDa polypeptide
DNA-directed RNA polymerase II subunit C
RNA polymerase II subunit 3
RNA polymerase II subunit B3
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
polymerase (RNA) II subunit C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032940.3NP_116558.1  DNA-directed RNA polymerase II subunit RPB3

    See identical proteins and their annotated locations for NP_116558.1

    Status: REVIEWED

    Source sequence(s)
    BC003159, BI458170
    Consensus CDS
    ENSP00000219252.4, ENST00000219252.10
    Conserved Domains (1) summary
    RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002694.2: Suppressed sequence

    NM_002694.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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