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Rpn2 ribophorin II [ Mus musculus (house mouse) ]

Gene ID: 20014, updated on 2-Nov-2024

Summary

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Official Symbol
Rpn2provided by MGI
Official Full Name
ribophorin IIprovided by MGI
Primary source
MGI:MGI:98085
See related
Ensembl:ENSMUSG00000027642 AllianceGenome:MGI:98085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpn-2; 1300012C06Rik
Summary
Predicted to enable ribosome binding activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in autophagosome membrane; endoplasmic reticulum; and nuclear body. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; ear; heart; and integumental system. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 112.6), genital fat pad adult (RPKM 107.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpn2 in Genome Data Viewer
Location:
2 H1; 2 78.2 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157121018..157168238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157279098..157326318)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen) Neighboring gene STARR-positive B cell enhancer ABC_E4514 Neighboring gene STARR-positive B cell enhancer ABC_E7877 Neighboring gene predicted gene, 57690 Neighboring gene maestro heat-like repeat family member 8 Neighboring gene STARR-seq mESC enhancer starr_06199 Neighboring gene STARR-seq mESC enhancer starr_06200 Neighboring gene STARR-seq mESC enhancer starr_06201 Neighboring gene STARR-positive B cell enhancer ABC_E818 Neighboring gene predicted gene, 54126 Neighboring gene growth hormone releasing hormone Neighboring gene predicted gene, 39974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leu promotes C2C12 cell differentiation by regulating the GSK3β/β-catenin signaling pathway through facilitating the interaction between SESN2 and RPN2. Liu Y, et al. J Sci Food Agric, 2024 Aug 30. PMID 38551359
  2. S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. Zmijewski JW, et al. J Biol Chem, 2009 Aug 14. PMID 19549781, Free PMC Article
  3. Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization. Löffler C, et al. Hum Genet, 1991 Jun. PMID 2066112
  4. Rat ribophorin II: molecular cloning and chromosomal localization of a highly conserved transmembrane glycoprotein of the rough endoplasmic reticulum. Pirozzi G, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1710116
  5. RPN2 gene confers docetaxel resistance in breast cancer. Honma K, et al. Nat Med, 2008 Sep. PMID 18724378

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leu promotes C2C12 cell differentiation by regulating the GSK3beta/beta-catenin signaling pathway through facilitating the interaction between SESN2 and RPN2.
    Title: Leu promotes C2C12 cell differentiation by regulating the GSK3β/β-catenin signaling pathway through facilitating the interaction between SESN2 and RPN2.
  2. S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
    Title: S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Names
RPN-II
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
ribophorin-2
NP_001342092.1
NP_001342093.1
NP_001342094.1
NP_062616.2
XP_006499084.1
XP_006499087.1
XP_030104723.1
XP_036015669.1
XP_036015671.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355163.1 → NP_001342092.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL669828
    UniProtKB/TrEMBL
    A2ACG7
    Related
    ENSMUSP00000029171.6, ENSMUST00000029171.6
    Conserved Domains (1) summary
    pfam05817
    Location:9 → 623
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  2. NM_001355164.1 → NP_001342093.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL669828
    UniProtKB/TrEMBL
    A2ACG7
    Conserved Domains (1) summary
    pfam05817
    Location:6 → 620
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  3. NM_001355165.1 → NP_001342094.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame 3' exon compared to variant 1.The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment comared to isoform 1.
    Source sequence(s)
    AL669828
    Related
    ENSMUST00000127252.8
    Conserved Domains (1) summary
    pfam05817
    Location:2 → 405
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  4. NM_019642.4 → NP_062616.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_062616.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame 3' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK004968
    Consensus CDS
    CCDS16975.1
    UniProtKB/Swiss-Prot
    A2ACG6, Q3TKY0, Q91XH0, Q9DBG6
    UniProtKB/TrEMBL
    Q61833
    Related
    ENSMUSP00000112081.3, ENSMUST00000116380.9
    Conserved Domains (1) summary
    pfam05817
    Location:9 → 623
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157121018..157168238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248863.2 → XP_030104723.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2

    UniProtKB/TrEMBL
    A2ACG7
    Conserved Domains (1) summary
    pfam05817
    Location:26 → 640
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  2. XM_006499024.4 → XP_006499087.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1

    UniProtKB/TrEMBL
    A2ACG7
    Conserved Domains (1) summary
    pfam05817
    Location:31 → 645
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  3. XM_006499021.5 → XP_006499084.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X3

    UniProtKB/TrEMBL
    Q61833
    Conserved Domains (1) summary
    pfam05817
    Location:31 → 645
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  4. XM_036159776.1 → XP_036015669.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X4

    UniProtKB/TrEMBL
    Q3U505
    Conserved Domains (1) summary
    pfam05817
    Location:26 → 640
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  5. XM_036159778.1 → XP_036015671.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X5

    UniProtKB/TrEMBL
    Q61833
    Conserved Domains (1) summary
    pfam05817
    Location:6 → 620
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBG6.1 GenPept UniProtKB/Swiss-Prot:Q9DBG6

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