U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rpn2 ribophorin II [ Mus musculus (house mouse) ]

Gene ID: 20014, updated on 8-Dec-2022

Summary

Official Symbol
Rpn2provided by MGI
Official Full Name
ribophorin IIprovided by MGI
Primary source
MGI:MGI:98085
See related
Ensembl:ENSMUSG00000027642 AllianceGenome:MGI:98085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpn-2; 1300012C06Rik
Summary
Predicted to enable ribosome binding activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in autophagosome membrane; nuclear body; and rough endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; ear; heart; and integumental system. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 112.6), genital fat pad adult (RPKM 107.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rpn2 in Genome Data Viewer
Location:
2 H1; 2 78.2 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157121018..157168238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157279098..157326318)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen) Neighboring gene U7 small nuclear RNA Neighboring gene maestro heat-like repeat family member 8 Neighboring gene predicted gene, 54126 Neighboring gene growth hormone releasing hormone Neighboring gene predicted gene, 39974

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Names
RPN-II
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
ribophorin-2
NP_001342092.1
NP_001342093.1
NP_001342094.1
NP_062616.2
XP_006499084.1
XP_006499087.1
XP_030104723.1
XP_036015669.1
XP_036015671.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355163.1NP_001342092.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL669828
    Related
    ENSMUSP00000029171.6, ENSMUST00000029171.6
    Conserved Domains (1) summary
    pfam05817
    Location:9623
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  2. NM_001355164.1NP_001342093.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL669828
    Conserved Domains (1) summary
    pfam05817
    Location:6620
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  3. NM_001355165.1NP_001342094.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame 3' exon compared to variant 1.The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment comared to isoform 1.
    Source sequence(s)
    AL669828
    Related
    ENSMUST00000127252.8
    Conserved Domains (1) summary
    pfam05817
    Location:2405
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  4. NM_019642.4NP_062616.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_062616.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame 3' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK004968
    Consensus CDS
    CCDS16975.1
    UniProtKB/Swiss-Prot
    Q91XH0, Q9DBG6
    Related
    ENSMUSP00000112081.3, ENSMUST00000116380.9
    Conserved Domains (1) summary
    pfam05817
    Location:9623
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157121018..157168238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248863.2XP_030104723.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam05817
    Location:26640
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  2. XM_006499024.4XP_006499087.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam05817
    Location:31645
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  3. XM_006499021.5XP_006499084.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam05817
    Location:31645
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  4. XM_036159776.1XP_036015669.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam05817
    Location:26640
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  5. XM_036159778.1XP_036015671.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam05817
    Location:6620
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II