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RPN2 ribophorin II [ Homo sapiens (human) ]

Gene ID: 6185, updated on 22-Aug-2021

Summary

Official Symbol
RPN2provided by HGNC
Official Full Name
ribophorin IIprovided by HGNC
Primary source
HGNC:HGNC:10382
See related
Ensembl:ENSG00000118705 MIM:180490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWP1; RPNII; RIBIIR; RPN-II
Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in thyroid (RPKM 122.3), placenta (RPKM 121.1) and 25 other tissues See more
Orthologs
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Genomic context

See RPN2 in Genome Data Viewer
Location:
20q11.23
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (37179161..37241623)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35807733..35870022)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor like 1 Neighboring gene RPS27A pseudogene 3 Neighboring gene maestro heat like repeat family member 8 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene growth hormone releasing hormone Neighboring gene mannosidase beta like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribophorin II (RPN2) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of oligosaccharyltransferase complex TAS
Traceable Author Statement
more info
PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
oligosaccharyltransferase complex subunit (non-catalytic)
ribophorin-2
NP_001129243.1
NP_001311228.1
NP_001311230.1
NP_001311231.1
NP_001311232.1
NP_001311233.1
NP_001311234.1
NP_001311235.1
NP_002942.2
XP_006723914.1
XP_006723915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042268.1 RefSeqGene

    Range
    5278..67567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135771.3NP_001129243.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001129243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2. Variants 2 and 3 are the same length and encode isoforms (2 and 3, respectively) of the same length but their variant and encoded isoform sequences are different.
    Source sequence(s)
    AK096243, BC002380, BF923732
    Consensus CDS
    CCDS46599.1
    UniProtKB/Swiss-Prot
    P04844
    Related
    ENSP00000362724.5, ENST00000373622.9
    Conserved Domains (1) summary
    pfam05817
    Location:9591
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  2. NM_001324299.2NP_001311228.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3. Variants 2 and 3 are the same length and encode isoforms (2 and 3, respectively) of the same length but their variant and encoded isoform sequences are different.
    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
  3. NM_001324301.2NP_001311230.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
    Conserved Domains (1) summary
    pfam05817
    Location:9639
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  4. NM_001324302.2NP_001311231.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
  5. NM_001324303.2NP_001311232.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
  6. NM_001324304.2NP_001311233.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 7. Variants 7 and 8 are the same length and encode isoforms (7 and 8, respectively) of the same length but their variant and encoded isoform sequences are different.
    Source sequence(s)
    AL031659, BC002380, BG718075
    UniProtKB/Swiss-Prot
    P04844
    Conserved Domains (1) summary
    pfam05817
    Location:9623
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  7. NM_001324305.2NP_001311234.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes isoform 8. Variants 7 and 8 are the same length and encode isoforms (7 and 8, respectively) of the same length but their variant and encoded isoform sequences are different.
    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
    Conserved Domains (1) summary
    pfam05817
    Location:9639
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  8. NM_001324306.2NP_001311235.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL031659, BC002380
    UniProtKB/Swiss-Prot
    P04844
  9. NM_002951.5NP_002942.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002942.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC002380, BC020222, BF923732, BG718075
    Consensus CDS
    CCDS13291.1
    UniProtKB/Swiss-Prot
    P04844
    Related
    ENSP00000237530.6, ENST00000237530.11
    Conserved Domains (1) summary
    pfam05817
    Location:9624
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    37179161..37241623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723851.3XP_006723914.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam05817
    Location:9607
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  2. XM_006723852.3XP_006723915.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam05817
    Location:9607
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
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