U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TXLNA taxilin alpha [ Homo sapiens (human) ]

Gene ID: 200081, updated on 6-Nov-2022

Summary

Official Symbol
TXLNAprovided by HGNC
Official Full Name
taxilin alphaprovided by HGNC
Primary source
HGNC:HGNC:30685
See related
Ensembl:ENSG00000084652 MIM:608676; AllianceGenome:HGNC:30685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL14; TXLN
Summary
Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.8), skin (RPKM 14.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TXLNA in Genome Data Viewer
Location:
1p35.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32179675..32198285)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32037572..32056187)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32645276..32663886)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39B Neighboring gene microRNA 5585 Neighboring gene Sharpr-MPRA regulatory region 5670 Neighboring gene karyopherin subunit alpha 6 Neighboring gene coiled-coil domain containing 28B Neighboring gene doublecortin domain containing 2B Neighboring gene IQ motif containing C Neighboring gene transmembrane protein 234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118870, MGC118871, DKFZp451J0118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
alpha-taxilin
Names
interleukin 14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376857.1NP_001363786.1  alpha-taxilin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Consensus CDS
    CCDS353.1
    UniProtKB/Swiss-Prot
    Q8N2Y3
    Related
    ENSP00000362711.1, ENST00000373609.1
    Conserved Domains (2) summary
    PRK07764
    Location:9161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09728
    Location:172477
    Taxilin; Myosin-like coiled-coil protein
  2. NM_001376858.1NP_001363787.1  alpha-taxilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Conserved Domains (1) summary
    pfam09728
    Location:1302
    Taxilin; Myosin-like coiled-coil protein
  3. NM_001376859.1NP_001363788.1  alpha-taxilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Conserved Domains (1) summary
    pfam09728
    Location:1302
    Taxilin; Myosin-like coiled-coil protein
  4. NM_175852.4NP_787048.1  alpha-taxilin isoform 1

    See identical proteins and their annotated locations for NP_787048.1

    Status: VALIDATED

    Source sequence(s)
    AL049795, AL832338, BC029686, BC046565
    Consensus CDS
    CCDS353.1
    UniProtKB/Swiss-Prot
    P40222, Q8N2Y3
    Related
    ENSP00000362712.3, ENST00000373610.8
    Conserved Domains (2) summary
    PRK07764
    Location:9161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09728
    Location:172477
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32179675..32198285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000563.2XP_016856052.1  alpha-taxilin isoform X1

  2. XM_011540932.3XP_011539234.1  alpha-taxilin isoform X2

    See identical proteins and their annotated locations for XP_011539234.1

    Conserved Domains (1) summary
    pfam09728
    Location:40318
    Taxilin; Myosin-like coiled-coil protein
  3. XM_017000561.2XP_016856050.1  alpha-taxilin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32037572..32056187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)