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Txlna taxilin alpha [ Mus musculus (house mouse) ]

Gene ID: 109658, updated on 12-May-2024

Summary

Official Symbol
Txlnaprovided by MGI
Official Full Name
taxilin alphaprovided by MGI
Primary source
MGI:MGI:105968
See related
Ensembl:ENSMUSG00000053841 AllianceGenome:MGI:105968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il14; Txln; 2600010N21Rik
Summary
Predicted to enable syntaxin binding activity. Acts upstream of or within B cell activation. Predicted to be located in cytoplasm. Is expressed in brain; metanephros; oviduct; spinal cord; and testis. Orthologous to human TXLNA (taxilin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 25.6), CNS E11.5 (RPKM 25.3) and 28 other tissues See more
Orthologs
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Genomic context

See Txlna in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129519870..129534867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129626077..129641065, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene IQ motif containing C Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene karyopherin subunit alpha 6 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC77972, MGC86145

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-taxilin
Names
interleukin 14
taxilin Txln

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005506.3NP_001005506.2  alpha-taxilin

    See identical proteins and their annotated locations for NP_001005506.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK168418, AW121192, BC060227
    Consensus CDS
    CCDS38887.1
    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Related
    ENSMUSP00000081285.6, ENSMUST00000084264.12
    Conserved Domains (1) summary
    pfam09728
    Location:170477
    Taxilin; Myosin-like coiled-coil protein
  2. NM_001199695.1NP_001186624.1  alpha-taxilin

    See identical proteins and their annotated locations for NP_001186624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK150240, AW121192, CJ151043
    Consensus CDS
    CCDS38887.1
    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Related
    ENSMUSP00000042153.10, ENSMUST00000046425.16
    Conserved Domains (1) summary
    pfam09728
    Location:170477
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129519870..129534867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502659.5XP_006502722.1  alpha-taxilin isoform X1

    See identical proteins and their annotated locations for XP_006502722.1

    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Conserved Domains (1) summary
    pfam09728
    Location:170477
    Taxilin; Myosin-like coiled-coil protein