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CDCP2 CUB domain containing protein 2 [ Homo sapiens (human) ]

Gene ID: 200008, updated on 1-Oct-2022

Summary

Official Symbol
CDCP2provided by HGNC
Official Full Name
CUB domain containing protein 2provided by HGNC
Primary source
HGNC:HGNC:27297
See related
Ensembl:ENSG00000157211 MIM:612320; AllianceGenome:HGNC:27297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in extracellular region. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CDCP2 in Genome Data Viewer
Location:
1p32.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54132687..54153000, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54015559..54035905, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54598360..54618673, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene microRNA 4781 Neighboring gene COX7B pseudogene 3 Neighboring gene cytochrome b5 reductase like Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene single stranded DNA binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
CUB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353655.3NP_001340584.1  CUB domain-containing protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL357673
    Consensus CDS
    CCDS85977.1
    UniProtKB/TrEMBL
    A0A1B0GU47
    Related
    ENSP00000489959.1, ENST00000530059.3
    Conserved Domains (3) summary
    cd00041
    Location:30141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:257370
    CUB; CUB domain
    cl27758
    Location:380463
    Zona_pellucida; Zona pellucida-like domain
  2. NM_001412141.1NP_001399070.1  CUB domain-containing protein 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses the same exon combination as variant (2) but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (3) has a frameshifted C-terminus compared to isoform 2.
    Source sequence(s)
    CP068277
  3. NM_201546.5NP_963840.2  CUB domain-containing protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_963840.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
    Source sequence(s)
    AL357673
    Consensus CDS
    CCDS588.2
    UniProtKB/Swiss-Prot
    Q5VXM1, Q6ZWJ3
    Related
    ENSP00000360381.1, ENST00000371330.1
    Conserved Domains (2) summary
    cd00041
    Location:30141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:257370
    CUB; CUB domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54132687..54153000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54015559..54035905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)