Format

Send to:

Choose Destination

CYB5RL cytochrome b5 reductase like [ Homo sapiens (human) ]

Gene ID: 606495, updated on 8-Jul-2021

Summary

Official Symbol
CYB5RLprovided by HGNC
Official Full Name
cytochrome b5 reductase likeprovided by HGNC
Primary source
HGNC:HGNC:32220
See related
Ensembl:ENSG00000215883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 1.8), adrenal (RPKM 1.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CYB5RL in Genome Data Viewer
Location:
1p32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54169651..54200030, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54635324..54665703, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene cytochrome c oxidase subunit 7B pseudogene Neighboring gene CUB domain containing protein 2 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene SSBP3 antisense RNA 1 Neighboring gene single stranded DNA binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: CDCP2

Homology

Clone Names

  • FLJ16295

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytochrome-b5 reductase activity, acting on NAD(P)H TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NADH-cytochrome b5 reductase-like
NP_001026842.2
NP_001340282.1
NP_001340283.1
NP_001340285.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031672.4NP_001026842.2  NADH-cytochrome b5 reductase-like isoform 1

    See identical proteins and their annotated locations for NP_001026842.2

    Status: VALIDATED

    Source sequence(s)
    AL357673
    Consensus CDS
    CCDS44151.1
    UniProtKB/Swiss-Prot
    Q6IPT4
    Related
    ENSP00000434343.1, ENST00000534324.6
    Conserved Domains (3) summary
    cd06183
    Location:80315
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:65315
    PTZ00319; NADH-cytochrome B5 reductase; Provisional
    pfam09791
    Location:1951
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  2. NM_001353353.2NP_001340282.1  NADH-cytochrome b5 reductase-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment (two exons) compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL357673
    Conserved Domains (2) summary
    cd06183
    Location:67236
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1951
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  3. NM_001353354.2NP_001340283.1  NADH-cytochrome b5 reductase-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL357673, BC012781, BC049198, BX478156
    Conserved Domains (1) summary
    cd06183
    Location:2167
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
  4. NM_001353356.2NP_001340285.1  NADH-cytochrome b5 reductase-like isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and uses an alternate internal splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL357673
    Consensus CDS
    CCDS85978.1
    Related
    ENSP00000431157.1, ENST00000497820.1
    Conserved Domains (2) summary
    pfam09791
    Location:1951
    Oxidored-like; Oxidoreductase-like protein, N-terminal
    cl26810
    Location:65116
    PLN02252; nitrate reductase [NADPH]

RNA

  1. NR_148414.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC071735, BX478156

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54169651..54200030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center