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TMEM201 transmembrane protein 201 [ Homo sapiens (human) ]

Gene ID: 199953, updated on 7-Jan-2024

Summary

Official Symbol
TMEM201provided by HGNC
Official Full Name
transmembrane protein 201provided by HGNC
Primary source
HGNC:HGNC:33719
See related
Ensembl:ENSG00000188807 AllianceGenome:HGNC:33719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ima1; NET5; SAMP1
Summary
Predicted to enable actin filament binding activity and lamin binding activity. Involved in centrosome localization; nuclear envelope organization; and protein localization to nuclear envelope. Located in nuclear envelope. Is integral component of nuclear inner membrane. Colocalizes with cortical endoplasmic reticulum and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.5), endometrium (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM201 in Genome Data Viewer
Location:
1p36.22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9588911..9614877)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9125255..9151173)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9648969..9674935)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9533371-9533922 Neighboring gene MPRA-validated peak54 silencer Neighboring gene Sharpr-MPRA regulatory region 9854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9601405-9601904 Neighboring gene solute carrier family 25 member 33 Neighboring gene MPRA-validated peak56 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 225 Neighboring gene hESC enhancers GRCh37_chr1:9653469-9654066 and GRCh37_chr1:9654067-9654663 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:9657808-9659007 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9671778-9672013 Neighboring gene uncharacterized LOC124903837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9675483-9676027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 226 Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 133 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 135 Neighboring gene PIK3CD antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lamin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear migration along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 201
Names
RP13-15M17.2
spindle-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010866.4NP_001010866.1  transmembrane protein 201 isoform 2

    See identical proteins and their annotated locations for NP_001010866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding region and 3' UTR and lacks multiple 3' exons, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC121187, BC137291
    Consensus CDS
    CCDS30579.1
    UniProtKB/Swiss-Prot
    Q5SNT2
    Related
    ENSP00000344772.5, ENST00000340305.9
    Conserved Domains (2) summary
    pfam09779
    Location:47169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192387
    DUF2448; Protein of unknown function C-terminus (DUF2448)
  2. NM_001130924.3NP_001124396.2  transmembrane protein 201 isoform 1

    See identical proteins and their annotated locations for NP_001124396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC137291, BE676679, BG828926, BX648377
    Consensus CDS
    CCDS44055.2
    UniProtKB/Swiss-Prot
    B9EH90, Q5SNT2, Q5SNT3
    UniProtKB/TrEMBL
    H0Y4R5
    Related
    ENSP00000344503.6, ENST00000340381.11
    Conserved Domains (2) summary
    pfam09779
    Location:47169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192379
    DUF2448; Protein of unknown function C-terminus (DUF2448)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9588911..9614877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000549.2XP_016856038.1  transmembrane protein 201 isoform X1

  2. XM_017000550.2XP_016856039.1  transmembrane protein 201 isoform X2

  3. XM_006710417.4XP_006710480.1  transmembrane protein 201 isoform X4

    UniProtKB/TrEMBL
    H0Y4R5
    Related
    ENSP00000393626.1, ENST00000416541.5
    Conserved Domains (2) summary
    pfam09779
    Location:47169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192379
    DUF2448; Protein of unknown function C-terminus (DUF2448)
  4. XM_047448441.1XP_047304397.1  transmembrane protein 201 isoform X5

  5. XM_011540910.3XP_011539212.1  transmembrane protein 201 isoform X6

    See identical proteins and their annotated locations for XP_011539212.1

    UniProtKB/Swiss-Prot
    Q5SNT2
    Conserved Domains (2) summary
    pfam09779
    Location:47169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192387
    DUF2448; Protein of unknown function C-terminus (DUF2448)
  6. XM_017000552.3XP_016856041.1  transmembrane protein 201 isoform X3

  7. XM_017000551.3XP_016856040.1  transmembrane protein 201 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9125255..9151173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334893.1XP_054190868.1  transmembrane protein 201 isoform X1

  2. XM_054334894.1XP_054190869.1  transmembrane protein 201 isoform X2

  3. XM_054334897.1XP_054190872.1  transmembrane protein 201 isoform X4

    UniProtKB/TrEMBL
    H0Y4R5
  4. XM_054334898.1XP_054190873.1  transmembrane protein 201 isoform X5

  5. XM_054334899.1XP_054190874.1  transmembrane protein 201 isoform X6

  6. XM_054334896.1XP_054190871.1  transmembrane protein 201 isoform X3

  7. XM_054334895.1XP_054190870.1  transmembrane protein 201 isoform X3