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TMEM201 transmembrane protein 201 [ Homo sapiens (human) ]

Gene ID: 199953, updated on 3-Nov-2024

Summary

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Official Symbol
TMEM201provided by HGNC
Official Full Name
transmembrane protein 201provided by HGNC
Primary source
HGNC:HGNC:33719
See related
Ensembl:ENSG00000188807 AllianceGenome:HGNC:33719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ima1; NET5; SAMP1
Summary
Predicted to enable actin filament binding activity and lamin binding activity. Involved in centrosome localization; nuclear envelope organization; and protein localization to nuclear envelope. Located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 3.5), endometrium (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM201 in Genome Data Viewer
Location:
1p36.22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9588911..9614877)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9125255..9151173)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9648969..9674935)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9533371-9533922 Neighboring gene MPRA-validated peak54 silencer Neighboring gene Sharpr-MPRA regulatory region 9854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9601405-9601904 Neighboring gene solute carrier family 25 member 33 Neighboring gene MPRA-validated peak56 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 225 Neighboring gene hESC enhancers GRCh37_chr1:9653469-9654066 and GRCh37_chr1:9654067-9654663 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:9657808-9659007 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9671778-9672013 Neighboring gene uncharacterized LOC124903837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9675483-9676027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 226 Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 133 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 135 Neighboring gene PIK3CD antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1. Bergqvist C, et al. Nucleic Acids Res, 2019 May 21. PMID 30793190, Free PMC Article
  2. Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis. Chen D, et al. Int J Mol Sci, 2023 Jun 17. PMID 37373430, Free PMC Article
  3. A transmembrane inner nuclear membrane protein in the mitotic spindle. Figueroa R, et al. Nucleus, 2010 May-Jun. PMID 21327071, Free PMC Article
  4. An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells. Bergqvist C, et al. Stem Cell Res, 2017 Aug. PMID 28668644
  5. Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1. Larsson VJ, et al. J Cell Sci, 2018 Apr 13. PMID 29514856, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis.
    Title: Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis.
  2. Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex.
    Title: Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex.
  3. Authors show that Samp1 is involved in the recruitment of HAUS6 and gamma-tubulin to the mitotic spindle. Samp1 is the first inner nuclear membrane protein shown to have a function in mitotic spindle assembly.
    Title: Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1.
  4. We also found that peripheral heterochromatin depended on the levels of the inner nuclear membrane protein Samp1, suggesting an important role in promoting peripheral heterochromatin. Taken together, FRIC is a powerful and robust new tool to study dynamic chromatin redistribution in live cells.
    Title: Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1.
  5. the mobility of YFP-Emerin was higher in Samp1 knock out cells and lower in cells overexpressing Samp1, suggesting that Samp1 significantly attenuates the mobility of Emerin in the nuclear envelope. The affinity between Samp1 and Emerin is decreased in the presence of Ran, suggesting that Ran attenuates the interaction between Samp1 and Emerin.
    Title: RanGTPase regulates the interaction between the inner nuclear membrane proteins, Samp1 and Emerin.
  6. Samp1 is involved in early differentiation of induced pluripotent stem cells.
    Title: An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells.
  7. the nucleoplasmic domains of Samp1 and Emerin can bind directly to each other.
    Title: MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells.
  8. characterization of a transmembrane protein of the nuclear envelope that we name spindle-associated membrane protein 1 (Samp1); Samp1 defines a specific membrane domain associated with the mitotic spindle
    Title: An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with cortical endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with spindle pole centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 201
Names
RP13-15M17.2
spindle-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010866.4 → NP_001010866.1  transmembrane protein 201 isoform 2

    See identical proteins and their annotated locations for NP_001010866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding region and 3' UTR and lacks multiple 3' exons, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC121187, BC137291
    Consensus CDS
    CCDS30579.1
    UniProtKB/Swiss-Prot
    Q5SNT2
    Related
    ENSP00000344772.5, ENST00000340305.9
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 387
    DUF2448; Protein of unknown function C-terminus (DUF2448)

  2. NM_001130924.3 → NP_001124396.2  transmembrane protein 201 isoform 1

    See identical proteins and their annotated locations for NP_001124396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC137291, BE676679, BG828926, BX648377
    Consensus CDS
    CCDS44055.2
    UniProtKB/Swiss-Prot
    B9EH90, Q5SNT2, Q5SNT3
    UniProtKB/TrEMBL
    H0Y4R5
    Related
    ENSP00000344503.6, ENST00000340381.11
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 379
    DUF2448; Protein of unknown function C-terminus (DUF2448)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9588911..9614877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000549.2 → XP_016856038.1  transmembrane protein 201 isoform X1

  2. XM_017000550.2 → XP_016856039.1  transmembrane protein 201 isoform X2

  3. XM_006710417.4 → XP_006710480.1  transmembrane protein 201 isoform X4

    UniProtKB/TrEMBL
    H0Y4R5
    Related
    ENSP00000393626.1, ENST00000416541.5
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 379
    DUF2448; Protein of unknown function C-terminus (DUF2448)

  4. XM_047448441.1 → XP_047304397.1  transmembrane protein 201 isoform X5

  5. XM_011540910.3 → XP_011539212.1  transmembrane protein 201 isoform X6

    See identical proteins and their annotated locations for XP_011539212.1

    UniProtKB/Swiss-Prot
    Q5SNT2
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 387
    DUF2448; Protein of unknown function C-terminus (DUF2448)

  6. XM_017000552.3 → XP_016856041.1  transmembrane protein 201 isoform X3

  7. XM_017000551.3 → XP_016856040.1  transmembrane protein 201 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9125255..9151173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334893.1 → XP_054190868.1  transmembrane protein 201 isoform X1

  2. XM_054334894.1 → XP_054190869.1  transmembrane protein 201 isoform X2

  3. XM_054334897.1 → XP_054190872.1  transmembrane protein 201 isoform X4

  4. XM_054334898.1 → XP_054190873.1  transmembrane protein 201 isoform X5

  5. XM_054334899.1 → XP_054190874.1  transmembrane protein 201 isoform X6

  6. XM_054334896.1 → XP_054190871.1  transmembrane protein 201 isoform X3

  7. XM_054334895.1 → XP_054190870.1  transmembrane protein 201 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SNT2.1 GenPept UniProtKB/Swiss-Prot:Q5SNT2

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