Tmem201 transmembrane protein 201 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem201provided by MGI
Official Full Name: transmembrane protein 201provided by MGI
Primary source: MGI:MGI:1196277
See related: Ensembl:ENSMUSG00000044700 AllianceGenome:MGI:1196277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Net5; Samp1; D4Ertd429e
Summary: Enables actin filament binding activity and lamin binding activity. Acts upstream of or within fibroblast migration and nuclear migration. Located in nuclear membrane. Orthologous to human TMEM201 (transmembrane protein 201). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 31.0), adrenal adult (RPKM 24.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 80.15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149799832..149822552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149715375..149738072, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
Title: Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
Title: Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice.
Title: Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.
data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis
Title: A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis.
In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex
Title: [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice].
At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction.
Title: Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1).
findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration
Title: Samp1 is a component of TAN lines and is required for nuclear movement.
Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C.
Title: Samp1 is a component of TAN lines and is required for nuclear movement.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

C86061 (e-PCR)
- UniSTS:207727

RH127250 (e-PCR)
- UniSTS:167394

RH142942 (e-PCR)
- UniSTS:232189

AV028368 (e-PCR)
- UniSTS:165375

Homology

Homologs of the Tmem201 gene: The Tmem201 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Orthologs from Annotation Pipeline: 499 organisms have orthologs with human gene Tmem201
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables lamin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables lamin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration along microtubule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization to nuclear envelope	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with cortical endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in nuclear membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 201

Names: spindle-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284270.1 → NP_001271199.1 transmembrane protein 201 isoform c

See identical proteins and their annotated locations for NP_001271199.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AK078532, AK086543, AL626808, BE987169, CA316211, CD353644, CD354653, CJ081115, CX562279

Consensus CDS

CCDS71523.1

UniProtKB/Swiss-Prot

A2A8U2, Q8BNY3

UniProtKB/TrEMBL

Q8C397

Related

ENSMUSP00000101312.3, ENSMUST00000105687.9

Conserved Domains (2) summary

pfam09779
Location:47 → 169

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:192 → 379

DUF2448; Protein of unknown function C-terminus (DUF2448)
NM_001284273.1 → NP_001271202.1 transmembrane protein 201 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains alternate 5' and 3' exon structure and initiates translation at a downstream start codon, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c.

Source sequence(s)

AK040555, AK079157, AK159041, AL626808

UniProtKB/Swiss-Prot

A2A8U2

UniProtKB/TrEMBL

Q3TXY3, Q8C9U2

Conserved Domains (2) summary

pfam09779
Location:3 → 125

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:148 → 343

DUF2448; Protein of unknown function C-terminus (DUF2448)
NM_177672.4 → NP_808340.2 transmembrane protein 201 isoform b

See identical proteins and their annotated locations for NP_808340.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 3' exon structure and lacks several exons in the 3' coding region, compared to variant 3. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform c.

Source sequence(s)

AK153631, AL626808, CJ081115

Consensus CDS

CCDS18965.1

UniProtKB/Swiss-Prot

A2A8U2

Related

ENSMUSP00000099497.2, ENSMUST00000103208.2

Conserved Domains (2) summary

pfam09779
Location:47 → 169

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:192 → 387

DUF2448; Protein of unknown function C-terminus (DUF2448)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

149799832..149822552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538820.5 → XP_006538883.1 transmembrane protein 201 isoform X1

Conserved Domains (2) summary

pfam09779
Location:47 → 169

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:192 → 379

DUF2448; Protein of unknown function C-terminus (DUF2448)
XM_006538822.3 → XP_006538885.1 transmembrane protein 201 isoform X3

Conserved Domains (2) summary

pfam09779
Location:2 → 79

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:102 → 289

DUF2448; Protein of unknown function C-terminus (DUF2448)
XM_006538821.4 → XP_006538884.1 transmembrane protein 201 isoform X2

Conserved Domains (2) summary

pfam09779
Location:3 → 125

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:148 → 335

DUF2448; Protein of unknown function C-terminus (DUF2448)
XM_006538823.5 → XP_006538886.1 transmembrane protein 201 isoform X4

Conserved Domains (2) summary

pfam09779
Location:47 → 169

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:192 → 379

DUF2448; Protein of unknown function C-terminus (DUF2448)

RNA

XR_003954938.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025106.1: Suppressed sequence

Description

NM_001025106.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.