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FYB2 FYN binding protein 2 [ Homo sapiens (human) ]

Gene ID: 199920, updated on 2-Nov-2024

Summary

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Official Symbol
FYB2provided by HGNC
Official Full Name
FYN binding protein 2provided by HGNC
Primary source
HGNC:HGNC:27295
See related
Ensembl:ENSG00000187889 MIM:618478; AllianceGenome:HGNC:27295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARAP; C1orf168
Summary
Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver (RPKM 2.0), kidney (RPKM 0.9) and 12 other tissues See more
Orthologs
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Genomic context

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See FYB2 in Genome Data Viewer
Location:
1p32.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (56718789..56826914, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (56597656..56710605, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (57184462..57285077, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 85 Neighboring gene uncharacterized LOC101929935 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:57230284-57230838 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8694 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1079 Neighboring gene complement C8 alpha chain Neighboring gene Sharpr-MPRA regulatory region 9770 Neighboring gene uncharacterized LOC112267900 Neighboring gene complement C8 beta chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Qi Q, et al. Hum Mol Genet, 2012 Nov 1. PMID 22843503, Free PMC Article
  2. ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion. Jung SH, et al. J Immunol, 2016 Aug 1. PMID 27335501
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FYN-binding protein 2
Names
RP4-758N20.2
activation-dependent, raft-recruited ADAP-like phosphoprotein
uncharacterized protein C1orf168

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004303.5 → NP_001004303.3  FYN-binding protein 2

    See identical proteins and their annotated locations for NP_001004303.3

    Status: VALIDATED

    Source sequence(s)
    AK093468, AL035705, BU686304, BX648439, DA523424, DB193989
    Consensus CDS
    CCDS30729.1
    UniProtKB/Swiss-Prot
    Q5VWT5, Q63HM3, Q6ZUY6
    Related
    ENSP00000345972.6, ENST00000343433.7
    Conserved Domains (1) summary
    cl17036
    Location:647 → 719
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    56718789..56826914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448402.1 → XP_047304358.1  FYN-binding protein 2 isoform X5

  2. XM_047448401.1 → XP_047304357.1  FYN-binding protein 2 isoform X5

  3. XM_047448403.1 → XP_047304359.1  FYN-binding protein 2 isoform X7

  4. XM_005270584.4 → XP_005270641.1  FYN-binding protein 2 isoform X6

    Conserved Domains (1) summary
    cl17036
    Location:539 → 611
    SH3; Src Homology 3 domain superfamily

  5. XM_047448400.1 → XP_047304356.1  FYN-binding protein 2 isoform X3

  6. XM_011540899.2 → XP_011539201.1  FYN-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cl17036
    Location:643 → 715
    SH3; Src Homology 3 domain superfamily

  7. XM_011540898.2 → XP_011539200.1  FYN-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cl17036
    Location:673 → 745
    SH3; Src Homology 3 domain superfamily

  8. XM_011540904.3 → XP_011539206.1  FYN-binding protein 2 isoform X10

    Conserved Domains (1) summary
    cl17036
    Location:365 → 437
    SH3; Src Homology 3 domain superfamily

  9. XM_011540906.4 → XP_011539208.1  FYN-binding protein 2 isoform X12

    Related
    ENST00000493000.5
    Conserved Domains (1) summary
    cl17036
    Location:303 → 375
    SH3; Src Homology 3 domain superfamily

  10. XM_011540903.3 → XP_011539205.1  FYN-binding protein 2 isoform X8

  11. XM_011540900.3 → XP_011539202.1  FYN-binding protein 2 isoform X4

  12. XM_047448410.1 → XP_047304366.1  FYN-binding protein 2 isoform X8

  13. XM_017000548.2 → XP_016856037.1  FYN-binding protein 2 isoform X9

  14. XM_011540905.3 → XP_011539207.1  FYN-binding protein 2 isoform X11

RNA

  1. XR_007095697.1 RNA Sequence

  2. XR_007095698.1 RNA Sequence

  3. XR_946570.2 RNA Sequence

  4. XR_001737026.2 RNA Sequence

  5. XR_946572.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    56597656..56710605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334879.1 → XP_054190854.1  FYN-binding protein 2 isoform X13

    UniProtKB/Swiss-Prot
    Q5VWT5, Q63HM3, Q6ZUY6

  2. XM_054334884.1 → XP_054190859.1  FYN-binding protein 2 isoform X5

  3. XM_054334883.1 → XP_054190858.1  FYN-binding protein 2 isoform X5

  4. XM_054334886.1 → XP_054190861.1  FYN-binding protein 2 isoform X7

  5. XM_054334885.1 → XP_054190860.1  FYN-binding protein 2 isoform X6

  6. XM_054334881.1 → XP_054190856.1  FYN-binding protein 2 isoform X3

  7. XM_054334880.1 → XP_054190855.1  FYN-binding protein 2 isoform X2

  8. XM_054334878.1 → XP_054190853.1  FYN-binding protein 2 isoform X1

  9. XM_054334890.1 → XP_054190865.1  FYN-binding protein 2 isoform X10

  10. XM_054334892.1 → XP_054190867.1  FYN-binding protein 2 isoform X12

  11. XM_054334888.1 → XP_054190863.1  FYN-binding protein 2 isoform X8

  12. XM_054334882.1 → XP_054190857.1  FYN-binding protein 2 isoform X4

  13. XM_054334887.1 → XP_054190862.1  FYN-binding protein 2 isoform X8

  14. XM_054334889.1 → XP_054190864.1  FYN-binding protein 2 isoform X9

  15. XM_054334891.1 → XP_054190866.1  FYN-binding protein 2 isoform X11

RNA

  1. XR_008485953.1 RNA Sequence

  2. XR_008485956.1 RNA Sequence

  3. XR_008485954.1 RNA Sequence

  4. XR_008485955.1 RNA Sequence

  5. XR_008485957.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VWT5.1 GenPept UniProtKB/Swiss-Prot:Q5VWT5

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