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FYB2 FYN binding protein 2 [ Homo sapiens (human) ]

Gene ID: 199920, updated on 5-Aug-2022

Summary

Official Symbol
FYB2provided by HGNC
Official Full Name
FYN binding protein 2provided by HGNC
Primary source
HGNC:HGNC:27295
See related
Ensembl:ENSG00000187889 MIM:618478; AllianceGenome:HGNC:27295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARAP; C1orf168
Summary
Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 2.0), kidney (RPKM 0.9) and 12 other tissues See more
Orthologs
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Genomic context

See FYB2 in Genome Data Viewer
Location:
1p32.2
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (56718789..56826914, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (56597656..56697943, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (57184462..57285077, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 85 Neighboring gene uncharacterized LOC101929935 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 2 Neighboring gene complement C8 alpha chain Neighboring gene Sharpr-MPRA regulatory region 9770

Genomic regions, transcripts, and products

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FYN-binding protein 2
Names
RP4-758N20.2
activation-dependent, raft-recruited ADAP-like phosphoprotein
uncharacterized protein C1orf168

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004303.5NP_001004303.3  FYN-binding protein 2

    See identical proteins and their annotated locations for NP_001004303.3

    Status: VALIDATED

    Source sequence(s)
    AK093468, AL035705, BU686304, BX648439, DA523424, DB193989
    Consensus CDS
    CCDS30729.1
    UniProtKB/Swiss-Prot
    Q5VWT5, Q6ZUY6
    Related
    ENSP00000345972.6, ENST00000343433.7
    Conserved Domains (1) summary
    cl17036
    Location:647719
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    56718789..56826914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448402.1XP_047304358.1  FYN-binding protein 2 isoform X5

  2. XM_047448401.1XP_047304357.1  FYN-binding protein 2 isoform X5

  3. XM_047448403.1XP_047304359.1  FYN-binding protein 2 isoform X7

  4. XM_005270584.4XP_005270641.1  FYN-binding protein 2 isoform X6

    Conserved Domains (1) summary
    cl17036
    Location:539611
    SH3; Src Homology 3 domain superfamily
  5. XM_047448400.1XP_047304356.1  FYN-binding protein 2 isoform X3

  6. XM_011540899.2XP_011539201.1  FYN-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cl17036
    Location:643715
    SH3; Src Homology 3 domain superfamily
  7. XM_011540898.2XP_011539200.1  FYN-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cl17036
    Location:673745
    SH3; Src Homology 3 domain superfamily
  8. XM_011540904.3XP_011539206.1  FYN-binding protein 2 isoform X10

    Conserved Domains (1) summary
    cl17036
    Location:365437
    SH3; Src Homology 3 domain superfamily
  9. XM_011540906.4XP_011539208.1  FYN-binding protein 2 isoform X12

    Related
    ENST00000493000.5
    Conserved Domains (1) summary
    cl17036
    Location:303375
    SH3; Src Homology 3 domain superfamily
  10. XM_011540903.3XP_011539205.1  FYN-binding protein 2 isoform X8

  11. XM_011540900.3XP_011539202.1  FYN-binding protein 2 isoform X4

  12. XM_047448410.1XP_047304366.1  FYN-binding protein 2 isoform X8

  13. XM_017000548.2XP_016856037.1  FYN-binding protein 2 isoform X9

  14. XM_011540905.3XP_011539207.1  FYN-binding protein 2 isoform X11

RNA

  1. XR_007095697.1 RNA Sequence

  2. XR_007095698.1 RNA Sequence

  3. XR_946570.2 RNA Sequence

  4. XR_001737026.2 RNA Sequence

  5. XR_946572.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    56597656..56697943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)