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Fyb2 FYN binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 242594, updated on 2-Oct-2018

Summary

Official Symbol
Fyb2provided by MGI
Official Full Name
FYN binding protein 2provided by MGI
Primary source
MGI:MGI:2685466
See related
Ensembl:ENSMUSG00000078612 Vega:OTTMUSG00000008126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARAP; Gm620; C1orf168; 1700024P16Rik
Expression
Broad expression in genital fat pad adult (RPKM 1.2), testis adult (RPKM 1.0) and 15 other tissues See more
Orthologs

Genomic context

See Fyb2 in Genome Data Viewer
Location:
4; 4 C6
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (104833832..105016864)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (104586061..104689468)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene disabled 1 Neighboring gene predicted gene, 36661 Neighboring gene complement component 8, beta polypeptide Neighboring gene predicted gene, 40216 Neighboring gene complement component 8, alpha polypeptide Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene predicted gene, 36835 Neighboring gene protein kinase, AMP-activated, alpha 2 catalytic subunit Neighboring gene predicted gene, 36893

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Clone Names

  • MGC169347

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FYN-binding protein 2; uncharacterized protein C1orf168 homolog
Names
activation-dependent, raft-recruited ADAP-like phosphoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162980.1NP_001156452.1  FYN-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001156452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK028077, AK133762, AL627186, AV174094
    Consensus CDS
    CCDS51250.1
    UniProtKB/TrEMBL
    E9PZ08
    Related
    ENSMUSP00000102415.2, ENSMUST00000106803.8
    Conserved Domains (1) summary
    cl17036
    Location:715787
    SH3; Src Homology 3 domain superfamily
  2. NM_001285952.1NP_001272881.1  FYN-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK028077, AK133762, AL627186
    Conserved Domains (1) summary
    cl17036
    Location:741813
    SH3; Src Homology 3 domain superfamily
  3. NM_001285953.1NP_001272882.1  FYN-binding protein 2 isoform c

    See identical proteins and their annotated locations for NP_001272882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK028077, AK133762, AL627186
    Conserved Domains (1) summary
    cl17036
    Location:624696
    SH3; Src Homology 3 domain superfamily

RNA

  1. NR_104376.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the central region, and includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK028077, AK133762, AL627186, AL929466

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    104833832..105016864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320219.1XP_017175708.1  uncharacterized protein C1orf168 homolog isoform X1

    UniProtKB/TrEMBL
    E9PZ08
    Conserved Domains (1) summary
    cl17036
    Location:715787
    SH3; Src Homology 3 domain superfamily
  2. XM_006503083.3XP_006503146.1  uncharacterized protein C1orf168 homolog isoform X2

    See identical proteins and their annotated locations for XP_006503146.1

    Conserved Domains (1) summary
    cl17036
    Location:624696
    SH3; Src Homology 3 domain superfamily
  3. XM_006503085.3XP_006503148.1  uncharacterized protein C1orf168 homolog isoform X3

    Conserved Domains (1) summary
    cl17036
    Location:401473
    SH3; Src Homology 3 domain superfamily
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