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ELF3 E74 like ETS transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 1999, updated on 12-Aug-2018
Official Symbol
ELF3provided by HGNC
Official Full Name
E74 like ETS transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:3318
See related
Ensembl:ENSG00000163435 MIM:602191; Vega:OTTHUMG00000035867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERT; ESX; EPR-1; ESE-1
Expression
Biased expression in colon (RPKM 88.6), stomach (RPKM 68.2) and 13 other tissues See more
Orthologs
See ELF3 in Genome Data Viewer
Location:
1q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202010562..202017188)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201979647..201986316)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268254 Neighboring gene arginyl aminopeptidase Neighboring gene ELF3 antisense RNA 1 Neighboring gene microRNA 6740 Neighboring gene FOXA motif-containing MPRA enhancer 200 Neighboring gene uncharacterized LOC105371684 Neighboring gene cysteine rich protein 1 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of E74-like factor 3 (ets domain transcription factor, epithelial-specific; ELF3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of E74-like factor 3 (ELF3) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland involution ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
ETS-related transcription factor Elf-3
Names
E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)
E74-like factor 3 (ets domain transcription factor)
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
epithelial-restricted with serine box
epithelium-restricted Ets protein ESX
epithelium-specific Ets transcription factor 1
ets domain transcription factor, serine box (epithelial-specific)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114309.1NP_001107781.1  ETS-related transcription factor Elf-3

    See identical proteins and their annotated locations for NP_001107781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC003569, BM976796, BQ023145, BX093212, CV570925, CV570991, DA591406
    Consensus CDS
    CCDS1419.1
    UniProtKB/Swiss-Prot
    P78545
    UniProtKB/TrEMBL
    A0A024R974
    Related
    ENSP00000356252.3, OTTHUMP00000034051, ENST00000367283.7, OTTHUMT00000087359
    Conserved Domains (2) summary
    cd08537
    Location:53132
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
    smart00413
    Location:272359
    ETS; erythroblast transformation specific domain
  2. NM_004433.4NP_004424.3  ETS-related transcription factor Elf-3

    See identical proteins and their annotated locations for NP_004424.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the shorter transcript (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC003569, BM976796, BQ023145, BX093212, CV570925, CV570991
    Consensus CDS
    CCDS1419.1
    UniProtKB/Swiss-Prot
    P78545
    UniProtKB/TrEMBL
    A0A024R974
    Related
    ENSP00000356253.5, OTTHUMP00000034050, ENST00000367284.9, OTTHUMT00000087358
    Conserved Domains (2) summary
    cd08537
    Location:53132
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
    smart00413
    Location:272359
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    202010562..202017188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244942.3XP_005244999.1  ETS-related transcription factor Elf-3 isoform X1

    Conserved Domains (1) summary
    cd08537
    Location:53132
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
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