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Rpa2 replication protein A2 [ Mus musculus (house mouse) ]

Gene ID: 19891, updated on 5-Jan-2023

Summary

Official Symbol
Rpa2provided by MGI
Official Full Name
replication protein A2provided by MGI
Primary source
MGI:MGI:1339939
See related
Ensembl:ENSMUSG00000028884 AllianceGenome:MGI:1339939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPA34; Rf-A2
Summary
Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; mitotic G1 DNA damage checkpoint signaling; and regulation of response to DNA damage stimulus. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in PML body and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region; nucleus; and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; and spermatocyte. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 35.0), liver E14.5 (RPKM 32.2) and 27 other tissues See more
Orthologs
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Genomic context

See Rpa2 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132495671..132506057)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132768360..132778746)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 8 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene protein phosphatase 1, regulatory subunit 8 Neighboring gene predicted gene, 22767

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
replication protein A 32 kDa subunit
Names
30-kDa protein
RF-A protein 2
RP-A p32
RP-A p34
replication factor A protein 2
replication protein A 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011284.3NP_035414.3  replication protein A 32 kDa subunit

    See identical proteins and their annotated locations for NP_035414.3

    Status: PROVISIONAL

    Source sequence(s)
    AK168680
    Consensus CDS
    CCDS18734.1
    UniProtKB/TrEMBL
    Q3TE40
    Related
    ENSMUSP00000099621.5, ENSMUST00000102561.11
    Conserved Domains (3) summary
    COG5235
    Location:6267
    RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
    cd04478
    Location:73167
    RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
    pfam08784
    Location:166262
    RPA_C; Replication protein A C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132495671..132506057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)