U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Robo1 roundabout guidance receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 19876, updated on 8-Feb-2024

Summary

Official Symbol
Robo1provided by MGI
Official Full Name
roundabout guidance receptor 1provided by MGI
Primary source
MGI:MGI:1274781
See related
Ensembl:ENSMUSG00000022883 AllianceGenome:MGI:1274781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUTT1; Gm310
Summary
Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within animal organ development; axon guidance; and negative regulation of cell population proliferation. Located in axolemma. Is expressed in several structures, including central nervous system; foot; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 19.0), whole brain E14.5 (RPKM 14.9) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Robo1 in Genome Data Viewer
Location:
16 C3.1; 16 41.08 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (71824406..72844379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (72027518..73047491)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41219 Neighboring gene STARR-seq mESC enhancer starr_41220 Neighboring gene signal recognition particle 72 pseudogene Neighboring gene signal recognition particle 72 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41221 Neighboring gene STARR-seq mESC enhancer starr_41222 Neighboring gene RIKEN cDNA 8030451O07 gene Neighboring gene STARR-seq mESC enhancer starr_41224 Neighboring gene STARR-seq mESC enhancer starr_41225 Neighboring gene STARR-seq mESC enhancer starr_41226 Neighboring gene STARR-seq mESC enhancer starr_41227 Neighboring gene predicted gene, 29908 Neighboring gene STARR-seq mESC enhancer starr_41230 Neighboring gene STARR-seq mESC enhancer starr_41231 Neighboring gene predicted gene, 52248 Neighboring gene STARR-seq mESC enhancer starr_41232 Neighboring gene STARR-seq mESC enhancer starr_41233 Neighboring gene STARR-seq mESC enhancer starr_41234 Neighboring gene RIKEN cDNA 4930500H12 gene Neighboring gene STARR-seq mESC enhancer starr_41237 Neighboring gene STARR-seq mESC enhancer starr_41239 Neighboring gene STARR-seq mESC enhancer starr_41240 Neighboring gene STARR-seq mESC enhancer starr_41241 Neighboring gene STARR-seq mESC enhancer starr_41242 Neighboring gene STARR-seq mESC enhancer starr_41243 Neighboring gene STARR-seq mESC enhancer starr_41244 Neighboring gene predicted gene, 25699

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables axon guidance receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Roundabout signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in aorta development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in aortic valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart induction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary duct terminal end bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in olfactory bulb interneuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415010.1NP_001401939.1  roundabout homolog 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC121890, AC124726, AC164551, CT025560
    UniProtKB/TrEMBL
    A0A338P6F7
  2. NM_019413.3NP_062286.2  roundabout homolog 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_062286.2

    Status: VALIDATED

    Source sequence(s)
    AC124726, AC164551
    Consensus CDS
    CCDS37376.1
    UniProtKB/Swiss-Prot
    O89026
    UniProtKB/TrEMBL
    G5E843
    Related
    ENSMUSP00000023600.8, ENSMUST00000023600.8
    Conserved Domains (8) summary
    cd05724
    Location:135219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:326415
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:522608
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:223308
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:739825
    fn3; Fibronectin type III domain
    cl11960
    Location:430503
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    71824406..72844379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522960.4XP_006523023.1  roundabout homolog 1 isoform X5

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:178262
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:283351
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:372461
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:71170
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:568654
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:785868
    fn3; Fibronectin type III domain
    pfam07679
    Location:462549
    I-set; Immunoglobulin I-set domain
  2. XM_036159819.1XP_036015712.1  roundabout homolog 1 isoform X7

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd00063
    Location:555641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:772858
    fn3; Fibronectin type III domain
    cd05724
    Location:164249
    IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05725
    Location:256338
    IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05726
    Location:346443
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:59157
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:450536
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
  3. XM_036159820.1XP_036015713.1  roundabout homolog 1 isoform X13

    UniProtKB/Swiss-Prot
    O89026
    Conserved Domains (7) summary
    cd00063
    Location:527613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:744830
    fn3; Fibronectin type III domain
    cd05724
    Location:136221
    IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05725
    Location:228310
    IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05726
    Location:318415
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:31129
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:422508
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
  4. XM_006522963.5XP_006523026.1  roundabout homolog 1 isoform X10

    UniProtKB/Swiss-Prot
    O89026
    Conserved Domains (7) summary
    cd05724
    Location:150234
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:255323
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:344433
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:43142
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:540626
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:757840
    fn3; Fibronectin type III domain
    pfam07679
    Location:434521
    I-set; Immunoglobulin I-set domain
  5. XM_017316894.3XP_017172383.1  roundabout homolog 1 isoform X4

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:181265
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:286354
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:375464
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:74173
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:571657
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:788871
    fn3; Fibronectin type III domain
    pfam07679
    Location:465552
    I-set; Immunoglobulin I-set domain
  6. XM_006522961.4XP_006523024.1  roundabout homolog 1 isoform X8

    UniProtKB/Swiss-Prot
    O89026
    Conserved Domains (7) summary
    cd05724
    Location:153237
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:258326
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:347436
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:46145
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:543629
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:760843
    fn3; Fibronectin type III domain
    pfam07679
    Location:437524
    I-set; Immunoglobulin I-set domain
  7. XM_006522958.3XP_006523021.1  roundabout homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:401490
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:597683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:814897
    fn3; Fibronectin type III domain
    pfam07679
    Location:491578
    I-set; Immunoglobulin I-set domain
  8. XM_006522964.5XP_006523027.1  roundabout homolog 1 isoform X12

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:401490
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:597683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:814897
    fn3; Fibronectin type III domain
    pfam07679
    Location:491578
    I-set; Immunoglobulin I-set domain
  9. XM_017316893.2XP_017172382.1  roundabout homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:401490
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:597683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:814897
    fn3; Fibronectin type III domain
    pfam07679
    Location:491578
    I-set; Immunoglobulin I-set domain
  10. XM_006522962.5XP_006523025.1  roundabout homolog 1 isoform X9

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:401490
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:597683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:814897
    fn3; Fibronectin type III domain
    pfam07679
    Location:491578
    I-set; Immunoglobulin I-set domain
  11. XM_006522957.3XP_006523020.1  roundabout homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A338P6F7
    Related
    ENSMUSP00000155958.2, ENSMUST00000232205.2
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:398487
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:594680
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:811894
    fn3; Fibronectin type III domain
    pfam07679
    Location:488575
    I-set; Immunoglobulin I-set domain
  12. XM_030249003.2XP_030104863.1  roundabout homolog 1 isoform X11

    UniProtKB/TrEMBL
    A0A338P6F7
    Conserved Domains (7) summary
    cd05724
    Location:207291
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:312380
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:398487
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:100199
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:594680
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:811894
    fn3; Fibronectin type III domain
    pfam07679
    Location:488575
    I-set; Immunoglobulin I-set domain
  13. XM_006522965.3XP_006523028.1  roundabout homolog 1 isoform X14

    UniProtKB/Swiss-Prot
    O89026
    Conserved Domains (7) summary
    cd05724
    Location:135219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:329418
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:525611
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:742825
    fn3; Fibronectin type III domain
    pfam07679
    Location:419506
    I-set; Immunoglobulin I-set domain
  14. XM_030249005.2XP_030104865.1  roundabout homolog 1 isoform X15

    UniProtKB/Swiss-Prot
    O89026
    Conserved Domains (7) summary
    cd05724
    Location:135219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:326415
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:522608
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:739822
    fn3; Fibronectin type III domain
    pfam07679
    Location:416503
    I-set; Immunoglobulin I-set domain