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EIF5 eukaryotic translation initiation factor 5 [ Homo sapiens (human) ]

Gene ID: 1983, updated on 4-Dec-2022

Summary

Official Symbol
EIF5provided by HGNC
Official Full Name
eukaryotic translation initiation factor 5provided by HGNC
Primary source
HGNC:HGNC:3299
See related
Ensembl:ENSG00000100664 MIM:601710; AllianceGenome:HGNC:3299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF-5; EIF-5A
Summary
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 60.5), thyroid (RPKM 44.5) and 25 other tissues See more
Orthologs
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Genomic context

See EIF5 in Genome Data Viewer
Location:
14q32.32
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103334237..103345025)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97570092..97580884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103800574..103811362)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370686 Neighboring gene CRISPRi-validated cis-regulatory element chr14.2493 Neighboring gene uncharacterized LOC105378183 Neighboring gene uncharacterized LOC105370687 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene high mobility group box 3 pseudogene 26 Neighboring gene ribosomal protein SA pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 5 (EIF5) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001969.5NP_001960.2  eukaryotic translation initiation factor 5

    See identical proteins and their annotated locations for NP_001960.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL138976
    Consensus CDS
    CCDS9980.1
    UniProtKB/Swiss-Prot
    P55010, Q9UG48
    UniProtKB/TrEMBL
    A0A024R6Q1
    Related
    ENSP00000216554.3, ENST00000216554.8
    Conserved Domains (2) summary
    cd11561
    Location:233385
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9128
    eIF-5_eIF-2B; Domain found in IF2B/IF5
  2. NM_183004.5NP_892116.2  eukaryotic translation initiation factor 5

    See identical proteins and their annotated locations for NP_892116.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL138976
    Consensus CDS
    CCDS9980.1
    UniProtKB/Swiss-Prot
    P55010, Q9UG48
    UniProtKB/TrEMBL
    A0A024R6Q1
    Related
    ENSP00000376477.2, ENST00000392715.6
    Conserved Domains (2) summary
    cd11561
    Location:233385
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103334237..103345025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97570092..97580884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)