Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ripk1provided by MGI
Official Full Name: receptor (TNFRSF)-interacting serine-threonine kinase 1provided by MGI
Primary source: MGI:MGI:108212
See related: Ensembl:ENSMUSG00000021408 AllianceGenome:MGI:108212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIP; Rinp; Rip1; RIP-1; D330015H01Rik
Summary: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13 A3.3; 13 14.01 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (34181072..34219153)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (34002225..34035170)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models.
Title: RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models.
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8.
Title: RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8.
Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury.
Title: Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury.
Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells.
Title: Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells.
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
Title: SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation.
Title: Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation.
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
Title: Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
RIPK1 and RIPK3 regulate TNFalpha-induced beta-cell death in concert with caspase activity.
Title: RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity.
Astrocyte-Derived TNF-alpha-Activated Platelets Promote Cerebral Ischemia/Reperfusion Injury by Regulating the RIP1/RIP3/AKT Signaling Pathway.
Title: Astrocyte-Derived TNF-α-Activated Platelets Promote Cerebral Ischemia/Reperfusion Injury by Regulating the RIP1/RIP3/AKT Signaling Pathway.
RIPK1 in Liver Parenchymal Cells Limits Murine Hepatitis during Acute CCl4-Induced Liver Injury.
Title: RIPK1 in Liver Parenchymal Cells Limits Murine Hepatitis during Acute CCl(4)-Induced Liver Injury.

Submit: New GeneRIF Correction See all GeneRIFs (210)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (15) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

U25995 (e-PCR)
- UniSTS:160282

PMC316425P1 (e-PCR)
- UniSTS:272990

Homology

Homologs of the Ripk1 gene: The Ripk1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Ripk1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables death domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell death	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrogen peroxide-induced cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of ATP:ADP antiporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in ripoptosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: receptor-interacting serine/threonine-protein kinase 1

Names: cell death protein RIP; receptor-interacting protein 1; serine/threonine-protein kinase RIP

NP_001346926.1

EC 2.7.11.1

NP_033094.3

EC 2.7.11.1

XP_006516672.1

EC 2.7.11.1

XP_030103066.1

EC 2.7.11.1

XP_036013820.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359997.1 → NP_001346926.1 receptor-interacting serine/threonine-protein kinase 1

Status: VALIDATED

Source sequence(s)

AC161117

Consensus CDS

CCDS26443.1

UniProtKB/Swiss-Prot

Q8CD90

Related

ENSMUSP00000021844.9, ENSMUST00000021844.15

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain
NM_009068.3 → NP_033094.3 receptor-interacting serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_033094.3

Status: VALIDATED

Source sequence(s)

BC054542

Consensus CDS

CCDS26443.1

UniProtKB/Swiss-Prot

Q60855, Q8CD90

Related

ENSMUSP00000129831.2, ENSMUST00000167374.9

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

34181072..34219153

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247206.2 → XP_030103066.1 receptor-interacting serine/threonine-protein kinase 1 isoform X2

Conserved Domains (3) summary

cd08777
Location:375 → 460

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

pfam12721
Location:303 → 343

RHIM; RIP homotypic interaction motif

cl21453
Location:1 → 98

PKc_like; Protein Kinases, catalytic domain
XM_006516609.5 → XP_006516672.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

See identical proteins and their annotated locations for XP_006516672.1

UniProtKB/Swiss-Prot

Q60855, Q8CD90

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain
XM_036157927.1 → XP_036013820.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

Q8CD90

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain