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Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 19766, updated on 12-Feb-2024

Summary

Official Symbol
Ripk1provided by MGI
Official Full Name
receptor (TNFRSF)-interacting serine-threonine kinase 1provided by MGI
Primary source
MGI:MGI:108212
See related
Ensembl:ENSMUSG00000021408 AllianceGenome:MGI:108212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIP; Rinp; Rip1; RIP-1; D330015H01Rik
Summary
Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ripk1 in Genome Data Viewer
Location:
13 A3.3; 13 14.01 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34181072..34219153)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34002225..34035170)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene biphenyl hydrolase like Neighboring gene tubulin, beta 2A class IIA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables death domain binding ISO
Inferred from Sequence Orthology
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ATP:ADP antiporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in ripoptosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 1
Names
cell death protein RIP
receptor-interacting protein 1
serine/threonine-protein kinase RIP
NP_001346926.1
NP_033094.3
XP_006516672.1
XP_030103066.1
XP_036013820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359997.1NP_001346926.1  receptor-interacting serine/threonine-protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    AC161117
    Consensus CDS
    CCDS26443.1
    UniProtKB/Swiss-Prot
    Q3U0J3, Q60855, Q8CD90
    UniProtKB/TrEMBL
    F7D1J2
    Related
    ENSMUSP00000021844.9, ENSMUST00000021844.15
    Conserved Domains (2) summary
    cd08777
    Location:568653
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23291
    PKc_like; Protein Kinases, catalytic domain
  2. NM_009068.3NP_033094.3  receptor-interacting serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_033094.3

    Status: VALIDATED

    Source sequence(s)
    BC054542
    Consensus CDS
    CCDS26443.1
    UniProtKB/Swiss-Prot
    Q3U0J3, Q60855, Q8CD90
    UniProtKB/TrEMBL
    F7D1J2
    Related
    ENSMUSP00000129831.2, ENSMUST00000167374.9
    Conserved Domains (2) summary
    cd08777
    Location:568653
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23291
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34181072..34219153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247206.2XP_030103066.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    Conserved Domains (3) summary
    cd08777
    Location:375460
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    pfam12721
    Location:303343
    RHIM; RIP homotypic interaction motif
    cl21453
    Location:198
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006516609.5XP_006516672.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006516672.1

    UniProtKB/Swiss-Prot
    Q3U0J3, Q60855, Q8CD90
    UniProtKB/TrEMBL
    F7D1J2
    Conserved Domains (2) summary
    cd08777
    Location:568653
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23291
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036157927.1XP_036013820.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0J3, Q60855, Q8CD90
    UniProtKB/TrEMBL
    F7D1J2
    Conserved Domains (2) summary
    cd08777
    Location:568653
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23291
    PKc_like; Protein Kinases, catalytic domain