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RIPK1 receptor interacting serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 8737, updated on 27-Nov-2022

Summary

Official Symbol
RIPK1provided by HGNC
Official Full Name
receptor interacting serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:10019
See related
Ensembl:ENSG00000137275 MIM:603453; AllianceGenome:HGNC:10019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP; RIP1; AIEFL; IMD57; RIP-1
Summary
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in gall bladder (RPKM 7.8), colon (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See RIPK1 in Genome Data Viewer
Location:
6p25.2
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (3063967..3115187)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (2932866..2983225)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3064201..3115421)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene serpin family B member 8 pseudogene 1 Neighboring gene uncharacterized LOC124901242 Neighboring gene RNA, 5S ribosomal pseudogene 201 Neighboring gene uncharacterized LOC107986556 Neighboring gene biphenyl hydrolase like Neighboring gene tubulin beta 2A class IIa

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autoinflammation with episodic fever and lymphadenopathy
MedGen: C5394286 OMIM: 618852 GeneReviews: Not available
Compare labs
Immunodeficiency 57
MedGen: C4748212 OMIM: 618108 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of preschool internalizing problems.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Overexpression of RIPK1 is induced by HIV-1 Vpr in the transfected 293T cells PubMed
retropepsin gag-pol PR cleavage of RIPK1 disrupts RIPK1 function PubMed
gag-pol Majority of RIPK1 cleavage occurs due to post-integration expression of proviral genes (not by virion delivered PR) and is completely inhibited with the addiition of Saquinavir (PR inhibitor) PubMed
gag-pol HIV-1 PR (WT, not D25N) cleaves endogeneously expressed (and over-expressed) RIPK1 with high specificity (RIPK1 amino acids L462-Y463) PubMed
gag-pol HIV-1 PR (D25N) binds RIPK1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables death domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables death receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in necroptotic process TAS
Traceable Author Statement
more info
 
involved_in necroptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hydrogen peroxide-induced cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in programmed necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ATP:ADP antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ripoptosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ripoptosome assembly involved in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 1
Names
cell death protein RIP
receptor (TNFRSF)-interacting serine-threonine kinase 1
receptor-interacting protein 1
receptor-interacting protein kinase 1
serine/threonine-protein kinase RIP
NP_001303990.1
NP_001341859.1
NP_001341860.1
NP_001341861.1
NP_001341862.1
NP_001341863.1
NP_003795.2
XP_006715300.2
XP_016866892.1
XP_016866893.1
XP_016866894.1
XP_047275401.1
XP_047275402.1
XP_047275403.1
XP_047275404.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_063914.1 RefSeqGene

    Range
    9654..56347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001317061.3NP_001303990.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB208926, AJ420482, AK314176, AL031963
    Conserved Domains (2) summary
    cd08777
    Location:420505
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:1127
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001354930.2NP_001341859.1  receptor-interacting serine/threonine-protein kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL031963
    Consensus CDS
    CCDS4482.1
    UniProtKB/Swiss-Prot
    Q59H33
    UniProtKB/TrEMBL
    A0A024QZU0
    Related
    ENSP00000259808.3, ENST00000259808.9
    Conserved Domains (2) summary
    cd08777
    Location:583668
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cd14027
    Location:23290
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1
  3. NM_001354931.2NP_001341860.1  receptor-interacting serine/threonine-protein kinase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031963
    Consensus CDS
    CCDS93851.1
    Related
    ENSP00000369773.3, ENST00000380409.3
    Conserved Domains (2) summary
    cd08777
    Location:537622
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23244
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001354932.2NP_001341861.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL031963
    Conserved Domains (2) summary
    cd08777
    Location:420505
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:1127
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001354933.2NP_001341862.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL031963
    Conserved Domains (2) summary
    cd08777
    Location:420505
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:1127
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001354934.2NP_001341863.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL031963
    Conserved Domains (2) summary
    cd08777
    Location:420505
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:1127
    PKc_like; Protein Kinases, catalytic domain
  7. NM_003804.6NP_003795.2  receptor-interacting serine/threonine-protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_003795.2

    Status: REVIEWED

    Source sequence(s)
    AB208926, AJ420482, AK314176, AL031963, U50062
    Consensus CDS
    CCDS4482.1
    UniProtKB/Swiss-Prot
    Q13546, Q59H33
    UniProtKB/TrEMBL
    A0A024QZU0
    Related
    ENST00000676758.1
    Conserved Domains (2) summary
    cd08777
    Location:583668
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cd14027
    Location:23290
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    3063967..3115187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419447.1XP_047275403.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q59H33
    UniProtKB/TrEMBL
    A0A024QZU0
  2. XM_047419448.1XP_047275404.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q59H33
    UniProtKB/TrEMBL
    A0A024QZU0
  3. XM_017011405.2XP_016866894.1  receptor-interacting serine/threonine-protein kinase 1 isoform X3

    Related
    ENST00000676995.1
    Conserved Domains (2) summary
    smart00221
    Location:22285
    STYKc; Protein kinase; unclassified specificity
    cd14027
    Location:23290
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1
  4. XM_006715237.4XP_006715300.2  receptor-interacting serine/threonine-protein kinase 1 isoform X3

    Conserved Domains (2) summary
    smart00221
    Location:22285
    STYKc; Protein kinase; unclassified specificity
    cd14027
    Location:23290
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1
  5. XM_047419445.1XP_047275401.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

  6. XM_047419446.1XP_047275402.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

  7. XM_017011403.2XP_016866892.1  receptor-interacting serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (2) summary
    cd08777
    Location:420505
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:1127
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017011404.3XP_016866893.1  receptor-interacting serine/threonine-protein kinase 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    2932866..2983225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)