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Dpf2 double PHD fingers 2 [ Mus musculus (house mouse) ]

Gene ID: 19708, updated on 17-Aug-2024

Summary

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Official Symbol
Dpf2provided by MGI
Official Full Name
double PHD fingers 2provided by MGI
Primary source
MGI:MGI:109529
See related
Ensembl:ENSMUSG00000024826 AllianceGenome:MGI:109529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Req; BAF45D; ubi-d4; 2210010M07Rik
Summary
Predicted to enable H3K9me3 modified histone binding activity; lysine-acetylated histone binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of myeloid progenitor cell differentiation; nervous system development; and regulation of transcription, DNA-templated. Predicted to act upstream of or within apoptotic process and chromatin organization. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human DPF2 (double PHD fingers 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 38.7), limb E14.5 (RPKM 38.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5946544..5962899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5896516..5912871, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5878208-5878317 Neighboring gene solute carrier family 25, member 45 Neighboring gene STARR-positive B cell enhancer ABC_E1522 Neighboring gene tigger transposable element derived 3 Neighboring gene STARR-positive B cell enhancer ABC_E7628 Neighboring gene predicted gene, 42067 Neighboring gene CDC42 effector protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8731

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. Mas G, et al. J Clin Invest, 2023 Jul 3. PMID 37200093, Free PMC Article
  2. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Zhang W, et al. Cell Stem Cell, 2019 Jan 3. PMID 30609396, Free PMC Article
  3. Structure and expression of two members of the d4 gene family in mouse. Mertsalov IB, et al. Mamm Genome, 2000 Jan. PMID 10602997
  4. Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells. Gabig TG, et al. J Biol Chem, 1994 Nov 25. PMID 7961935
  5. The d4 gene family in the human genome. Chestkov AV, et al. Genomics, 1996 Aug 15. PMID 8812431

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
    Title: The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
  2. Dpf2 Loss Affects ESC Self-Renewal and Leads to Increased Apoptosis and Cell-Cycle Defects.
    Title: The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation.
  3. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
    Title: SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables H3K9me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein ubi-d4
Names
BRG1-associated factor 45D
D4, zinc and double PHD fingers family 2
apoptosis response zinc finger protein
neuro-d4/requiem
protein requiem

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291078.1 → NP_001278007.1  zinc finger protein ubi-d4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC142098, AK004812, BB839618, BY294588, CX207082
    Consensus CDS
    CCDS70920.1
    UniProtKB/TrEMBL
    D3Z5N6, Q3UKV4
    Related
    ENSMUSP00000113465.2, ENSMUST00000118623.2
    Conserved Domains (3) summary
    cd15530
    Location:343 → 388
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15691
    Location:286 → 341
    PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
    pfam14051
    Location:13 → 79
    Requiem_N; N-terminal domain of DPF2/REQ

  2. NM_011262.5 → NP_035392.1  zinc finger protein ubi-d4 isoform 2

    See identical proteins and their annotated locations for NP_035392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC142098, AK004812, BB839618, BY294588
    Consensus CDS
    CCDS37892.1
    UniProtKB/Swiss-Prot
    Q3UNP5, Q60663, Q61103, Q9QYA3
    UniProtKB/TrEMBL
    Q3UKV4
    Related
    ENSMUSP00000120125.2, ENSMUST00000136983.8
    Conserved Domains (3) summary
    cd15530
    Location:329 → 374
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15691
    Location:272 → 327
    PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
    pfam14051
    Location:13 → 79
    Requiem_N; N-terminal domain of DPF2/REQ

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5946544..5962899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61103.1 GenPept UniProtKB/Swiss-Prot:Q61103

Gene LinkOut

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