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Relb avian reticuloendotheliosis viral (v-rel) oncogene related B [ Mus musculus (house mouse) ]

Gene ID: 19698, updated on 18-Apr-2024

Summary

Official Symbol
Relbprovided by MGI
Official Full Name
avian reticuloendotheliosis viral (v-rel) oncogene related Bprovided by MGI
Primary source
MGI:MGI:103289
See related
Ensembl:ENSMUSG00000002983 AllianceGenome:MGI:103289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
shep
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; antigen processing and presentation; and mononuclear cell differentiation. Located in cytosol and nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 33.2), adrenal adult (RPKM 28.7) and 15 other tissues See more
Orthologs
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Genomic context

Location:
7 A3; 7 9.93 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19340142..19363352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19606217..19629438, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 296 Neighboring gene CLK4-associating serine/arginine rich protein Neighboring gene STARR-positive B cell enhancer ABC_E1720 Neighboring gene cleft lip and palate associated transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4901 Neighboring gene apolipoprotein C2 like Neighboring gene apolipoprotein C2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143683, MGC143684

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IEP
Inferred from Expression Pattern
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290457.2NP_001277386.1  transcription factor RelB isoform 2

    See identical proteins and their annotated locations for NP_001277386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC149052
    Consensus CDS
    CCDS71896.1
    UniProtKB/TrEMBL
    Q3U0K7, Q8K220
    Related
    ENSMUSP00000050166.9, ENSMUST00000049912.15
    Conserved Domains (4) summary
    cd07886
    Location:100271
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16179
    Location:279375
    RHD_dimer; Rel homology dimerization domain
    pfam16180
    Location:172
    RelB_leu_zip; RelB leucine zipper
    pfam16181
    Location:378555
    RelB_transactiv; RelB transactivation domain
  2. NM_001417183.1NP_001404112.1  transcription factor RelB isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149052
  3. NM_001417184.1NP_001404113.1  transcription factor RelB isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149052
  4. NM_001417185.1NP_001404114.1  transcription factor RelB isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149052
  5. NM_009046.3NP_033072.2  transcription factor RelB isoform 1

    See identical proteins and their annotated locations for NP_033072.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC149052
    Consensus CDS
    CCDS39799.1
    UniProtKB/Swiss-Prot
    Q04863, Q8VE46
    UniProtKB/TrEMBL
    Q3U0K7
    Related
    ENSMUSP00000092355.4, ENSMUST00000094762.10
    Conserved Domains (4) summary
    cd07886
    Location:103274
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16179
    Location:282378
    RHD_dimer; Rel homology dimerization domain
    pfam16180
    Location:175
    RelB_leu_zip; RelB leucine zipper
    pfam16181
    Location:381558
    RelB_transactiv; RelB transactivation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19340142..19363352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250461.4XP_011248763.1  transcription factor RelB isoform X1

    See identical proteins and their annotated locations for XP_011248763.1

    UniProtKB/TrEMBL
    Q3U0K7
    Conserved Domains (3) summary
    cd07886
    Location:46217
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16181
    Location:324501
    RelB_transactiv; RelB transactivation domain
    pfam16179
    Location:225320
    RHD_dimer; Rel homology dimerization domain
  2. XM_011250459.4XP_011248761.1  transcription factor RelB isoform X1

    See identical proteins and their annotated locations for XP_011248761.1

    UniProtKB/TrEMBL
    Q3U0K7
    Conserved Domains (3) summary
    cd07886
    Location:46217
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16181
    Location:324501
    RelB_transactiv; RelB transactivation domain
    pfam16179
    Location:225320
    RHD_dimer; Rel homology dimerization domain
  3. XM_006539675.2XP_006539738.1  transcription factor RelB isoform X1

    See identical proteins and their annotated locations for XP_006539738.1

    UniProtKB/TrEMBL
    Q3U0K7
    Conserved Domains (3) summary
    cd07886
    Location:46217
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16181
    Location:324501
    RelB_transactiv; RelB transactivation domain
    pfam16179
    Location:225320
    RHD_dimer; Rel homology dimerization domain
  4. XM_011250460.4XP_011248762.1  transcription factor RelB isoform X1

    See identical proteins and their annotated locations for XP_011248762.1

    UniProtKB/TrEMBL
    Q3U0K7
    Conserved Domains (3) summary
    cd07886
    Location:46217
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16181
    Location:324501
    RelB_transactiv; RelB transactivation domain
    pfam16179
    Location:225320
    RHD_dimer; Rel homology dimerization domain
  5. XM_036152807.1XP_036008700.1  transcription factor RelB isoform X2

    Conserved Domains (3) summary
    pfam16179
    Location:42138
    RHD_dimer; Rel homology dimerization domain
    pfam16181
    Location:141318
    RelB_transactiv; RelB transactivation domain
    cl08275
    Location:134
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)