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RELB RELB proto-oncogene, NF-kB subunit [ Homo sapiens (human) ]

Gene ID: 5971, updated on 4-Oct-2020

Summary

Official Symbol
RELBprovided by HGNC
Official Full Name
RELB proto-oncogene, NF-kB subunitprovided by HGNC
Primary source
HGNC:HGNC:9956
See related
Ensembl:ENSG00000104856 MIM:604758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IREL; I-REL; IMD53; REL-B
Expression
Broad expression in bone marrow (RPKM 14.1), appendix (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See RELB in Genome Data Viewer
Location:
19q13.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45001449..45038194)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45504707..45541456)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene APOC4-APOC2 readthrough (NMD candidate) Neighboring gene apolipoprotein C2 Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking Neighboring gene CLK4 associating serine/arginine rich protein Neighboring gene RNA, U6 small nuclear 611, pseudogene Neighboring gene zinc finger protein 296 Neighboring gene gem nuclear organelle associated protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection induces basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of v-rel avian reticuloendotheliosis viral oncogene homolog B (RELB) in human cells PubMed
tat NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat PubMed
tat HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays PubMed
tat NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat PubMed
tat HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD) PubMed
tat HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR PubMed
tat p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat PubMed
tat Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis PubMed
tat Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide PubMed
tat HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis PubMed
tat HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat PubMed
Vpr vpr HIV-1 Vpr stimulates non-canonical NFKappaB pathway by inducing the phosphorylation of NFKappaB2 (p100) at serine 866, which leads to process p100 into RelB/p52 and its subsequent nuclear translocation PubMed
vpr RelB promotes Vpr-induced cell cycle G2/M arrest PubMed
vpr HIV-1 Vpr interacts with RelB to promote the Vpr-mediated activation of NF-kappaB reporter gene and to enhance the transactivation of HIV LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
T-helper 1 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 
cellular response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor RelB
Names
v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006509.4NP_006500.2  transcription factor RelB

    See identical proteins and their annotated locations for NP_006500.2

    Status: VALIDATED

    Source sequence(s)
    BC028013, BM684710, DA940587
    Consensus CDS
    CCDS46110.1
    UniProtKB/Swiss-Prot
    Q01201
    Related
    ENSP00000221452.7, ENST00000221452.13
    Conserved Domains (4) summary
    cd07886
    Location:125296
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16181
    Location:403579
    RelB_transactiv; RelB transactivation domain
    pfam16179
    Location:304400
    RHD_dimer; Rel homology dimerisation domain
    pfam16180
    Location:1896
    RelB_leu_zip; RelB leucine zipper

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45001449..45038194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259128.2XP_005259185.1  transcription factor RelB isoform X2

    Conserved Domains (4) summary
    cd07886
    Location:125296
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16180
    Location:18110
    RelB_leu_zip; RelB leucine zipper
    pfam16181
    Location:331507
    RelB_transactiv; RelB transactivation domain
    cl15674
    Location:303331
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. XM_005259127.3XP_005259184.1  transcription factor RelB isoform X1

    See identical proteins and their annotated locations for XP_005259184.1

    UniProtKB/TrEMBL
    D6R992
    Related
    ENSP00000423287.1, ENST00000505236.1
    Conserved Domains (4) summary
    cd07886
    Location:122293
    RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
    pfam16179
    Location:301397
    RHD_dimer; Rel homology dimerization domain
    pfam16180
    Location:18107
    RelB_leu_zip; RelB leucine zipper
    pfam16181
    Location:400576
    RelB_transactiv; RelB transactivation domain
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