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DNAH10 dynein axonemal heavy chain 10 [ Homo sapiens (human) ]

Gene ID: 196385, updated on 12-May-2019

Summary

Official Symbol
DNAH10provided by HGNC
Official Full Name
dynein axonemal heavy chain 10provided by HGNC
Primary source
HGNC:HGNC:2941
See related
Ensembl:ENSG00000197653 MIM:605884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 3.1), bone marrow (RPKM 0.9) and 3 other tissues See more
Orthologs

Genomic context

See DNAH10 in Genome Data Viewer
Location:
12q24.31
Exon count:
79
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (123761995..123935720)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124246786..124420267)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370042 Neighboring gene tectonic family member 2 Neighboring gene ATPase H+ transporting V0 subunit a2 Neighboring gene ribosomal protein L27 pseudogene 12 Neighboring gene uncharacterized LOC105370044 Neighboring gene ZNF664-RFLNA readthrough Neighboring gene coiled-coil domain containing 92 Neighboring gene zinc finger protein 664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

Pathways from BioSystems

  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38262, FLJ43486, FLJ43808, KIAA2017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein heavy chain 10, axonemal
Names
axonemal beta dynein heavy chain 10
ciliary dynein heavy chain 10
dynein, axonemal, heavy polypeptide 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207437.3NP_997320.2  dynein heavy chain 10, axonemal

    See identical proteins and their annotated locations for NP_997320.2

    Status: VALIDATED

    Source sequence(s)
    AB290168, AC079315, AC117503, AL046294, DV080260, DV080609
    Consensus CDS
    CCDS9255.2
    UniProtKB/Swiss-Prot
    Q8IVF4
    UniProtKB/TrEMBL
    B0I1S1
    Related
    ENSP00000489675.1, ENST00000638045.1
    Conserved Domains (6) summary
    pfam03028
    Location:37644460
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:243758
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12571660
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30453378
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34073623
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:17942022
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    123761995..123935720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538020.2XP_011536322.1  dynein heavy chain 10, axonemal isoform X10

    Conserved Domains (3) summary
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005253555.3XP_005253612.1  dynein heavy chain 10, axonemal isoform X1

    Conserved Domains (6) summary
    pfam03028
    Location:38824578
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31633496
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35253741
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_017018960.1XP_016874449.1  dynein heavy chain 10, axonemal isoform X5

  4. XM_011538016.2XP_011536318.1  dynein heavy chain 10, axonemal isoform X4

    Conserved Domains (6) summary
    pfam03028
    Location:38194515
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31003433
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34623678
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011538014.2XP_011536316.1  dynein heavy chain 10, axonemal isoform X2

    Conserved Domains (6) summary
    pfam03028
    Location:38294525
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31103443
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34723688
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017018961.1XP_016874450.1  dynein heavy chain 10, axonemal isoform X6

  7. XM_011538015.3XP_011536317.1  dynein heavy chain 10, axonemal isoform X3

    Conserved Domains (6) summary
    pfam03028
    Location:38194515
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31003433
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34623678
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:28213088
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_011538017.3XP_011536319.1  dynein heavy chain 10, axonemal isoform X7

    Conserved Domains (6) summary
    pfam03028
    Location:37704466
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:304876
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13751778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30513384
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34133629
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:27723039
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011538019.2XP_011536321.1  dynein heavy chain 10, axonemal isoform X8

    Conserved Domains (5) summary
    pfam03028
    Location:28293525
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:322725
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:21102443
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:24722688
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:8591087
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_017018962.1XP_016874451.1  dynein heavy chain 10, axonemal isoform X9

  11. XM_024448875.1XP_024304643.1  dynein heavy chain 10, axonemal isoform X11

    Conserved Domains (3) summary
    pfam03028
    Location:12992001
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12781
    Location:9411158
    AAA_9; ATP-binding dynein motor region D5
    cl25937
    Location:131681
    MT; Microtubule-binding stalk of dynein motor

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187590.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    177..109264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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