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EFNA2 ephrin A2 [ Homo sapiens (human) ]

Gene ID: 1943, updated on 1-Jun-2020

Summary

Official Symbol
EFNA2provided by HGNC
Official Full Name
ephrin A2provided by HGNC
Primary source
HGNC:HGNC:3222
See related
Ensembl:ENSG00000099617 MIM:602756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELF-1; EPLG6; LERK6; HEK7-L; LERK-6
Summary
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 3.0), colon (RPKM 2.7) and 5 other tissues See more
Orthologs

Genomic context

See EFNA2 in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1282817..1301431)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1286153..1301430)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CIRBP antisense RNA 1 Neighboring gene cold inducible RNA binding protein Neighboring gene family with sequence similarity 174 member C Neighboring gene ribosomal protein S15 pseudogene 9 Neighboring gene PWWP domain containing 3A, DNA repair factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
olfactory bulb development IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ephrin-A2
Names
HEK7 ligand
eph-related receptor tyrosine kinase ligand 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405.4NP_001396.2  ephrin-A2 precursor

    See identical proteins and their annotated locations for NP_001396.2

    Status: REVIEWED

    Source sequence(s)
    AC004258
    Consensus CDS
    CCDS12061.1
    UniProtKB/Swiss-Prot
    O43921
    Related
    ENSP00000215368.1, ENST00000215368.4
    Conserved Domains (1) summary
    cd10425
    Location:35171
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1282817..1301431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026449.1XP_016881938.1  ephrin-A2 isoform X1

  2. XM_017026450.1XP_016881939.1  ephrin-A2 isoform X2

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