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Efna2 ephrin A2 [ Mus musculus (house mouse) ]

Gene ID: 13637, updated on 26-Sep-2022

Summary

Official Symbol
Efna2provided by MGI
Official Full Name
ephrin A2provided by MGI
Primary source
MGI:MGI:102707
See related
Ensembl:ENSMUSG00000003070 AllianceGenome:MGI:102707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Elf1; Epl6; CEK7L; Eplg6; Lerk6
Summary
Enables ephrin receptor binding activity. Involved in bone remodeling; ephrin receptor signaling pathway; and osteoclast differentiation. Predicted to be located in neuromuscular junction and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and limb. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.0), whole brain E14.5 (RPKM 18.4) and 16 other tissues See more
Orthologs
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Genomic context

See Efna2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80015316..80025844)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80179482..80190010)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene cold inducible RNA binding protein Neighboring gene family with sequence similarity 174, member C Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ephrin-A2
Names
CEK7-ligand
EPH related receptor tyrosine kinase ligand 6
ephrin A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007909.3NP_031935.3  ephrin-A2 precursor

    See identical proteins and their annotated locations for NP_031935.3

    Status: VALIDATED

    Source sequence(s)
    AC159999, AK140544, CF740879
    Consensus CDS
    CCDS24013.1
    UniProtKB/Swiss-Prot
    P52801
    UniProtKB/TrEMBL
    A0A6P5QLF1, A0A8C6MS42, Q3USB4
    Related
    ENSMUSP00000003154.6, ENSMUST00000003154.7
    Conserved Domains (1) summary
    cd10425
    Location:31167
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80015316..80025844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)