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Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 19417, updated on 21-Apr-2024

Summary

Official Symbol
Rasgrf1provided by MGI
Official Full Name
RAS protein-specific guanine nucleotide-releasing factor 1provided by MGI
Primary source
MGI:MGI:99694
See related
Ensembl:ENSMUSG00000032356 AllianceGenome:MGI:99694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnrp; Grf1; p190; CDC25; P190-A; CDC25Mm; Grfbeta; Ras-GRF1; p190RhoGEF
Summary
Enables glutamate receptor binding activity. Involved in activation of GTPase activity; neuron projection development; and regulation of Rac protein signal transduction. Acts upstream of or within cell population proliferation; regulation of NMDA receptor activity; and regulation of neuronal synaptic plasticity. Located in cytosol and growth cone. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 26.4), frontal lobe adult (RPKM 25.1) and 6 other tissues See more
Orthologs
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Genomic context

Location:
9 E3.1; 9 47.31 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89791565..89909032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (89909508..90026979)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24878 Neighboring gene RIKEN cDNA 4930524O08 gene Neighboring gene microRNA 184 Neighboring gene STARR-positive B cell enhancer ABC_E10577 Neighboring gene STARR-seq mESC enhancer starr_24879 Neighboring gene thymidine kinase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24880 Neighboring gene STARR-positive B cell enhancer ABC_E6787 Neighboring gene cathepsin H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of NMDA receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ras-specific guanine nucleotide-releasing factor 1
Names
Ras guanine release factor beta
ras-specific nucleotide exchange factor CDC25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039655.1NP_001034744.1  ras-specific guanine nucleotide-releasing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001034744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and uses an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 2, also known as GRF beta) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102545, AK140227
    Consensus CDS
    CCDS40723.1
    UniProtKB/TrEMBL
    A0A087WS68, Q9QZR7
    Related
    ENSMUSP00000034909.5, ENSMUST00000034909.11
    Conserved Domains (2) summary
    pfam00169
    Location:2482
    PH; PH domain
    cl17171
    Location:1992
    PH-like; Pleckstrin homology-like domain
  2. NM_001357743.1NP_001344672.1  ras-specific guanine nucleotide-releasing factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
    Source sequence(s)
    AC102545
    Conserved Domains (6) summary
    smart00147
    Location:10211257
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:246427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam00618
    Location:636685
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:925994
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:19155
    PH-like; Pleckstrin homology-like domain
    cl25508
    Location:105218
    Spc7; Spc7 kinetochore protein
  3. NM_001357744.1NP_001344673.1  ras-specific guanine nucleotide-releasing factor 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102545, DV043084
    UniProtKB/TrEMBL
    P70317
    Conserved Domains (1) summary
    cl17171
    Location:19108
    PH-like; Pleckstrin homology-like domain
  4. NM_011245.2NP_035375.1  ras-specific guanine nucleotide-releasing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_035375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC102545, AK079638, AK140380, CD775453
    Consensus CDS
    CCDS40722.1
    UniProtKB/Swiss-Prot
    P27671
    UniProtKB/TrEMBL
    B2RS27
    Related
    ENSMUSP00000034912.5, ENSMUST00000034912.6
    Conserved Domains (6) summary
    smart00147
    Location:10231259
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:248429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam00169
    Location:24130
    PH; PH domain
    pfam00618
    Location:638687
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:927996
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:19155
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    89791565..89909032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154723.1XP_036010616.1  ras-specific guanine nucleotide-releasing factor 1 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:597833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:212261
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:501570
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:9160
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_001778822.3 RNA Sequence