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Rad52 RAD52 homolog, DNA repair protein [ Mus musculus (house mouse) ]

Gene ID: 19365, updated on 5-Mar-2019

Summary

Official Symbol
Rad52provided by MGI
Official Full Name
RAD52 homolog, DNA repair proteinprovided by MGI
Primary source
MGI:MGI:101949
See related
Ensembl:ENSMUSG00000030166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rad52yh
Expression
Ubiquitous expression in thymus adult (RPKM 3.7), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs

Genomic context

See Rad52 in Genome Data Viewer
Location:
6 F1; 6 56.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (119902198..119922827)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119852716..119872841)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene microRNA 706 Neighboring gene ninjurin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA double-strand break processing involved in repair via single-strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA recombinase assembly IEA
Inferred from Electronic Annotation
more info
 
DNA recombination ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
PubMed 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
DNA repair protein RAD52 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166381.1NP_001159853.1  DNA repair protein RAD52 homolog isoform 1

    See identical proteins and their annotated locations for NP_001159853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC117667, AK080702, BE852444, CJ057181
    Consensus CDS
    CCDS51887.1
    UniProtKB/Swiss-Prot
    P43352
    Related
    ENSMUSP00000125502.1, ENSMUST00000162461.6
    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52
  2. NM_001166382.1NP_001159854.1  DNA repair protein RAD52 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC117667, AK080702, BE852444, CJ057181
    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52
  3. NM_001166383.1NP_001159855.1  DNA repair protein RAD52 homolog isoform 2

    See identical proteins and their annotated locations for NP_001159855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117667, AK080702, CJ057181
    UniProtKB/TrEMBL
    Q8VEE2
    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52
  4. NM_011236.2NP_035366.2  DNA repair protein RAD52 homolog isoform 4

    See identical proteins and their annotated locations for NP_035366.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC117667, AK080702, BE852444, CJ057181
    Consensus CDS
    CCDS20477.1
    UniProtKB/TrEMBL
    G5E879
    Related
    ENSMUSP00000032269.6, ENSMUST00000032269.11
    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52

RNA

  1. NR_149727.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1.This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC117667

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    119902198..119922827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505767.3XP_006505830.1  DNA repair protein RAD52 homolog isoform X5

    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52
  2. XM_006505765.3XP_006505828.1  DNA repair protein RAD52 homolog isoform X3

    Conserved Domains (1) summary
    cl01936
    Location:1144
    Rad52_Rad22; Rad52/22 family double-strand break repair protein
  3. XM_011241256.2XP_011239558.1  DNA repair protein RAD52 homolog isoform X2

    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52
  4. XM_006505766.3XP_006505829.1  DNA repair protein RAD52 homolog isoform X4

    Conserved Domains (1) summary
    cl01936
    Location:39117
    Rad52_Rad22; Rad52/22 family double-strand break repair protein
  5. XM_006505764.3XP_006505827.1  DNA repair protein RAD52 homolog isoform X1

    See identical proteins and their annotated locations for XP_006505827.1

    UniProtKB/TrEMBL
    Q8VEE2
    Conserved Domains (1) summary
    TIGR00607
    Location:39200
    rad52; recombination protein rad52

RNA

  1. XR_001785111.1 RNA Sequence

  2. XR_001785110.1 RNA Sequence

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