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Rad52 RAD52 homolog, DNA repair protein [ Mus musculus (house mouse) ]

Gene ID: 19365, updated on 2-Nov-2024

Summary

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Official Symbol
Rad52provided by MGI
Official Full Name
RAD52 homolog, DNA repair proteinprovided by MGI
Primary source
MGI:MGI:101949
See related
Ensembl:ENSMUSG00000030166 AllianceGenome:MGI:101949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rad52yh
Summary
Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Involved in DNA double-strand break processing involved in repair via single-strand annealing. Acts upstream of or within cellular response to oxidative stress and double-strand break repair via homologous recombination. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 3.7), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rad52 in Genome Data Viewer
Location:
6 F1; 6 56.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119878781..119899789)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119901722..119922827)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene STARR-seq mESC enhancer starr_17154 Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_17155 Neighboring gene STARR-seq mESC enhancer starr_17156 Neighboring gene STARR-positive B cell enhancer mm9_chr6:119988697-119988998 Neighboring gene STARR-positive B cell enhancer ABC_E1708 Neighboring gene STARR-positive B cell enhancer ABC_E8832 Neighboring gene STARR-positive B cell enhancer ABC_E11333 Neighboring gene microRNA 706 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120061967-120062268 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120062467-120062768 Neighboring gene STARR-seq mESC enhancer starr_17160 Neighboring gene ninjurin 2 Neighboring gene predicted gene, 25327

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of small polyadenylated B2 RNA. Kramerov DA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414725, Free PMC Article
  2. Genetic control of intrachromosomal recombination. Klein HL. Bioessays, 1995 Feb. PMID 7748165
  3. Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Bendixen C, et al. Genomics, 1994 Sep 1. PMID 7829098
  4. Genomic characterization of the mouse homolog of the Saccharomyces cerevisiae recombination and double-strand break repair gene RAD52. van den Ouweland J, et al. Mutat Res, 1997 Mar 12. PMID 9088345
  5. Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Rijkers T, et al. Mol Cell Biol, 1998 Nov. PMID 9774658, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rad52 mediates class-switch DNA recombination to IgD.
    Title: Rad52 mediates class-switch DNA recombination to IgD.
  2. RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization.
    Title: RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization.
  3. Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes.
    Title: The concerted roles of FANCM and Rad52 in the protection of common fragile sites.
  4. Rad52 competes with Ku for binding to S-region double-strand DNA breaks (DSB) free ends, where it facilitates a DSB synaptic process, which favours intra-S region recombination.
    Title: Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.
  5. Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene, implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell.
    Title: Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.
  6. In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
    Title: Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.
  7. Rad54 has a key function in maintaining genomic integrity of the developing germ cells.
    Title: Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress.
  8. Results indicate that RAD52 cooperates with OGG1 to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
    Title: The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells.
  9. RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
    Title: Suppression of retroviral infection by the RAD52 DNA repair protein.
  10. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.
    Title: Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in DNA double-strand break processing involved in repair via single-strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in DNA recombinase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
DNA repair protein RAD52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166381.2 → NP_001159853.1  DNA repair protein RAD52 homolog isoform 1

    See identical proteins and their annotated locations for NP_001159853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC117667
    Consensus CDS
    CCDS51887.1
    UniProtKB/Swiss-Prot
    P43352
    Related
    ENSMUSP00000125502.2, ENSMUST00000162461.7
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  2. NM_001166382.2 → NP_001159854.1  DNA repair protein RAD52 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC117667
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  3. NM_001410284.1 → NP_001397213.1  DNA repair protein RAD52 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117667

  4. NM_001410285.1 → NP_001397214.1  DNA repair protein RAD52 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117667

  5. NM_001410286.1 → NP_001397215.1  DNA repair protein RAD52 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117667

  6. NM_001410287.1 → NP_001397216.1  DNA repair protein RAD52 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC117667

  7. NM_001410288.1 → NP_001397217.1  DNA repair protein RAD52 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117667

  8. NM_001410289.1 → NP_001397218.1  DNA repair protein RAD52 homolog isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC117667

  9. NM_001410290.1 → NP_001397219.1  DNA repair protein RAD52 homolog isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC117667

  10. NM_011236.3 → NP_035366.2  DNA repair protein RAD52 homolog isoform 4

    See identical proteins and their annotated locations for NP_035366.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC117667
    Consensus CDS
    CCDS20477.1
    UniProtKB/TrEMBL
    G5E879
    Related
    ENSMUSP00000032269.7, ENSMUST00000032269.12
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

RNA

  1. NR_149727.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1.This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC117667
    Related
    ENSMUST00000161045.8

  2. NR_176974.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

  3. NR_176975.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

  4. NR_176977.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

  5. NR_176978.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

  6. NR_176979.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

  7. NR_176980.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117667

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119878781..119899789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505764.5 → XP_006505827.1  DNA repair protein RAD52 homolog isoform X1

    See identical proteins and their annotated locations for XP_006505827.1

    UniProtKB/TrEMBL
    Q8VEE2
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  2. XM_006505765.5 → XP_006505828.1  DNA repair protein RAD52 homolog isoform X4

    Conserved Domains (1) summary
    cl01936
    Location:1 → 144
    Rad52_Rad22; Rad52/22 family double-strand break repair protein

  3. XM_011241256.4 → XP_011239558.1  DNA repair protein RAD52 homolog isoform X2

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  4. XM_006505766.5 → XP_006505829.1  DNA repair protein RAD52 homolog isoform X5

    Conserved Domains (1) summary
    cl01936
    Location:39 → 117
    Rad52_Rad22; Rad52/22 family double-strand break repair protein

  5. XM_036165959.1 → XP_036021852.1  DNA repair protein RAD52 homolog isoform X4

    Conserved Domains (1) summary
    cl01936
    Location:1 → 144
    Rad52_Rad22; Rad52/22 family double-strand break repair protein

RNA

  1. XR_001785110.2 RNA Sequence

  2. XR_001785111.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001166383.1: Suppressed sequence

    Description
    NM_001166383.1: This RefSeq was removed because currently there is insufficient support for the 3'' end of the transcript and the C-terminus of the protein.

  2. NR_176976.1: Suppressed sequence

    Description
    NR_176976.1: This RefSeq was removed because of redundancy with NR_176975.1.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43352.1 GenPept UniProtKB/Swiss-Prot:P43352

Gene LinkOut

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