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Rad51 RAD51 recombinase [ Mus musculus (house mouse) ]

Gene ID: 19361, updated on 5-Jan-2023

Summary

Official Symbol
Rad51provided by MGI
Official Full Name
RAD51 recombinaseprovided by MGI
Primary source
MGI:MGI:97890
See related
Ensembl:ENSMUSG00000027323 AllianceGenome:MGI:97890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Reca; Rad51a
Summary
Enables chromatin binding activity and single-stranded DNA binding activity. Involved in telomere maintenance via recombination and telomere maintenance via telomere lengthening. Acts upstream of or within several processes, including DNA metabolic process; cellular response to hydroxyurea; and chromosome organization. Located in chromosome, telomeric region; cytoplasm; and lateral element. Is expressed in several structures, including brain; compacted morula; gonad; hemolymphoid system; and paravertebral ganglion. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 14.2), liver E14 (RPKM 13.5) and 13 other tissues See more
Orthologs
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Genomic context

See Rad51 in Genome Data Viewer
Location:
2 E5; 2 59.92 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118943295..118966554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119112814..119136073)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA serine 7 (anticodon GCT) Neighboring gene kinetochore scaffold 1 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene GTP cyclohydrolase I feedback regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA strand exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA strand exchange activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA strand exchange activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA recombinase assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to alkaloid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to camptothecin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair involved in meiotic recombination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A monoubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
involved_in male meiosis I IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA ligation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reciprocal meiotic recombination TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA damage checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in telomere maintenance via telomere lengthening IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within telomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synaptonemal complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA repair protein RAD51 homolog 1
Names
RAD51 homolog A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011234.5NP_035364.1  DNA repair protein RAD51 homolog 1

    See identical proteins and their annotated locations for NP_035364.1

    Status: VALIDATED

    Source sequence(s)
    AL772264
    Consensus CDS
    CCDS16590.1
    UniProtKB/Swiss-Prot
    Q08297, Q3UAY5
    UniProtKB/TrEMBL
    A0A6P5R7X2, A0A8C6I5T8
    Related
    ENSMUSP00000028795.4, ENSMUST00000028795.10
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51

RNA

  1. NR_156017.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI592821, AK011242, AK045050, AK148165

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118943295..118966554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)