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RAD51 RAD51 recombinase [ Homo sapiens (human) ]

Gene ID: 5888, updated on 21-Jan-2020

Summary

Official Symbol
RAD51provided by HGNC
Official Full Name
RAD51 recombinaseprovided by HGNC
Primary source
HGNC:HGNC:9817
See related
Ensembl:ENSG00000051180 MIM:179617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Biased expression in testis (RPKM 6.6), bone marrow (RPKM 3.5) and 13 other tissues See more
Orthologs

Genomic context

See RAD51 in Genome Data Viewer
Location:
15q15.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40694774..40732340)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40987327..41024356)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ser (anticodon GCT) 4-2 Neighboring gene kinetochore scaffold 1 Neighboring gene RNA, 7SL, cytoplasmic 376, pseudogene Neighboring gene RAD51 antisense RNA 1 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene SUMO2 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed
tat In PC12 cells treated with genotoxic agents, HIV-1 Tat reduces DNA breakage and increases repair of DNA double-strand breaks through a mechanism involving the upregulation of Rad51, a key regulator of homologous recombination in cells PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes HRAD51, during Tat-mediated transactivation of the HIV-1 LTR PubMed
Vpr vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
integrase gag-pol K133A RAD51 mutant remains to bind DNA but is unable to form an active nucleofilament due to the poor binding of ATP, which results in the defect on IN inhibition PubMed
gag-pol RAD51 protein inhibits the integration catalyzed by HIV-1 integrase both in vitro, in yeast expressing integrase and in infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
recombinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA-dependent ATP-dependent DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombinase assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA recombination TAS
Traceable Author Statement
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to camptothecin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydroxyurea IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via homologous recombination TAS
Traceable Author Statement
more info
PubMed 
interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
positive regulation of DNA ligation IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
replication fork processing IDA
Inferred from Direct Assay
more info
PubMed 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication-born double-strand break repair via sister chromatid exchange IEA
Inferred from Electronic Annotation
more info
 
response to X-ray IEA
Inferred from Electronic Annotation
more info
 
response to glucoside IEA
Inferred from Electronic Annotation
more info
 
strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance via recombination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed nuclear chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lateral element IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA repair protein RAD51 homolog 1
Names
BRCA1/BRCA2-containing complex, subunit 5
RAD51 homolog A
RecA, E. coli, homolog of
RecA-like protein
recombination protein A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012120.1 RefSeqGene

    Range
    5014..42180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164269.2NP_001157741.1  DNA repair protein RAD51 homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001157741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 2. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC012476, AC022405, AK131299
    Consensus CDS
    CCDS53931.1
    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000372088.3, ENST00000382643.7
    Conserved Domains (3) summary
    cd01123
    Location:116336
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    TIGR02239
    Location:25340
    recomb_RAD51; DNA repair protein RAD51
    pfam14520
    Location:3277
    HHH_5; Helix-hairpin-helix domain
  2. NM_001164270.2NP_001157742.1  DNA repair protein RAD51 homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001157742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' coding region and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 2. The resulting isoform (3) contains a distinct segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC012476, D14134, EU362635
    Consensus CDS
    CCDS53932.1
    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000406602.2, ENST00000423169.6
    Conserved Domains (1) summary
    cl26757
    Location:25258
    Rad51; Rad51
  3. NM_002875.5NP_002866.2  DNA repair protein RAD51 homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_002866.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct segment near the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC012476, AK313503
    Consensus CDS
    CCDS10062.1
    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000267868.3, ENST00000267868.8
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
  4. NM_133487.4NP_597994.3  DNA repair protein RAD51 homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_597994.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC012476, AK291969
    Consensus CDS
    CCDS53931.1
    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000493712.2, ENST00000645673.2
    Conserved Domains (3) summary
    cd01123
    Location:116336
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    TIGR02239
    Location:25340
    recomb_RAD51; DNA repair protein RAD51
    pfam14520
    Location:3277
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40694774..40732340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521861.2XP_011520163.1  DNA repair protein RAD51 homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_011520163.1

    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (1) summary
    cl26757
    Location:25258
    Rad51; Rad51
  2. XM_011521857.2XP_011520159.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011520159.1

    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
  3. XM_011521862.3XP_011520164.1  DNA repair protein RAD51 homolog 1 isoform X3

    Conserved Domains (2) summary
    smart00382
    Location:1182
    AAA; ATPases associated with a variety of cellular activities
    cd01123
    Location:1211
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
  4. XM_011521860.2XP_011520162.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011520162.1

    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
  5. XM_006720626.3XP_006720689.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006720689.1

    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
  6. XM_011521858.2XP_011520160.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011520160.1

    UniProtKB/Swiss-Prot
    Q06609
    Related
    ENSP00000433924.2, ENST00000532743.6
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
  7. XM_011521859.2XP_011520161.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011520161.1

    UniProtKB/Swiss-Prot
    Q06609
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
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