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EEF1D eukaryotic translation elongation factor 1 delta [ Homo sapiens (human) ]

Gene ID: 1936, updated on 1-Jun-2020

Summary

Official Symbol
EEF1Dprovided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 deltaprovided by HGNC
Primary source
HGNC:HGNC:3211
See related
Ensembl:ENSG00000104529 MIM:130592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF1D; EF-1D; FP1047
Summary
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues See more
Orthologs

Genomic context

See EEF1D in Genome Data Viewer
Location:
8q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143579694..143597675, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144661867..144679845, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene maestro heat like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene GDP-L-fucose synthase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat The second exon of HIV-1 Tat (amino acids 73-86) binds to EF-1delta (amino acids 144-280), thereby dramatically reducing the efficiency of the translation of cellular, but not viral, mRNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20897

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
elongation factor 1-delta
Names
EF-1-delta
antigen NY-CO-4
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130053.4NP_001123525.3  elongation factor 1-delta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1, also known as L).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6404.1
    Related
    ENSP00000484536.1, ENST00000618139.2
  2. NM_001130055.3NP_001123527.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001123527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AI366989, AK225040, BI667117, BQ686171, DA948687
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000388261.2, ENST00000419152.6
    Conserved Domains (2) summary
    pfam00736
    Location:198281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  3. NM_001130056.4NP_001123528.1  elongation factor 1-delta isoform 4

    See identical proteins and their annotated locations for NP_001123528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
    Source sequence(s)
    AC067930, AI366989, AK225040, BC094806, BI667117
    Consensus CDS
    CCDS47930.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000431763.1, ENST00000528610.5
    Conserved Domains (2) summary
    pfam00736
    Location:174257
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:135162
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  4. NM_001130057.3NP_001123529.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001123529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AC067930, AI366989, AK225040, BG748894, BQ064320, CF128478
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000317399.6, ENST00000317198.10
    Conserved Domains (2) summary
    pfam00736
    Location:198281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  5. NM_001195203.3NP_001182132.1  elongation factor 1-delta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an additional in-frame exon and uses an alternate in-frame splice site in the CDS. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC067930, AI366989, AK225040, AK293339, BI667117
    Consensus CDS
    CCDS56559.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000436507.1, ENST00000526838.5
    Conserved Domains (2) summary
    pfam00736
    Location:179262
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:140167
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  6. NM_001289950.3NP_001276879.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001276879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and intiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000434872.1, ENST00000529272.5
    Conserved Domains (2) summary
    pfam00736
    Location:198281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  7. NM_001317743.3NP_001304672.1  elongation factor 1-delta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
    Source sequence(s)
    AC067930, AI366989, AK225040, BG482145, BI667117
    Consensus CDS
    CCDS47930.1
    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:174257
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:135162
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  8. NM_001330646.2NP_001317575.1  elongation factor 1-delta isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS47930.1
    UniProtKB/Swiss-Prot
    P29692
  9. NM_001960.6NP_001951.2  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001951.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AC067930, AI366989, AK225040, BC012819, BI667117
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000378551.3, ENST00000395119.7
    Conserved Domains (2) summary
    pfam00736
    Location:198281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  10. NM_032378.6NP_115754.4  elongation factor 1-delta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1, also known as L).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6404.1
    Related
    ENSP00000391944.2, ENST00000442189.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143579694..143597675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516905.2XP_011515207.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_011515207.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  2. XM_024447089.1XP_024302857.1  elongation factor 1-delta isoform X3

    Conserved Domains (2) summary
    pfam00736
    Location:540623
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:501528
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  3. XM_006716523.2XP_006716586.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006716586.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  4. XM_017013171.1XP_016868660.1  elongation factor 1-delta isoform X2

    Conserved Domains (2) summary
    pfam00736
    Location:563646
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:524551
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  5. XM_005250823.1XP_005250880.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_005250880.1

    UniProtKB/Swiss-Prot
    P29692
    Related
    ENSP00000410059.2, ENST00000423316.6
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  6. XM_006716525.1XP_006716588.1  elongation factor 1-delta isoform X4

    See identical proteins and their annotated locations for XP_006716588.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:198281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  7. XM_011516906.3XP_011515208.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_011515208.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  8. XM_017013170.2XP_016868659.1  elongation factor 1-delta isoform X1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  9. XM_024447088.1XP_024302856.1  elongation factor 1-delta isoform X2

    Conserved Domains (2) summary
    pfam00736
    Location:563646
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:524551
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  10. XM_017013172.1XP_016868661.1  elongation factor 1-delta isoform X3

    Conserved Domains (2) summary
    pfam00736
    Location:540623
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:501528
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  11. XM_006716522.1XP_006716585.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006716585.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  12. XM_006716519.4XP_006716582.2  elongation factor 1-delta isoform X2

    Conserved Domains (2) summary
    pfam00736
    Location:563646
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:524551
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  13. XM_006716520.4XP_006716583.2  elongation factor 1-delta isoform X3

    Conserved Domains (2) summary
    pfam00736
    Location:540623
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:501528
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  14. XM_005250820.4XP_005250877.2  elongation factor 1-delta isoform X1

    Related
    ENSP00000434070.1, ENST00000532741.5
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  15. XM_006716524.1XP_006716587.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006716587.1

    UniProtKB/Swiss-Prot
    P29692
    Conserved Domains (2) summary
    pfam00736
    Location:564647
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:525552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    69734..87715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130054.1: Suppressed sequence

    Description
    NM_001130054.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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