Rab33b RAB33B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab33bprovided by MGI
Official Full Name: RAB33B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1330805
See related: Ensembl:ENSMUSG00000027739 AllianceGenome:MGI:1330805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in autophagosome assembly. Located in Golgi lumen. Used to study Smith-McCort dysplasia 2. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Orthologous to human RAB33B (RAB33B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in bladder adult (RPKM 9.3), CNS E18 (RPKM 5.9) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 3 C; 3 22.49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (51391387..51403649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (51483966..51496228)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the Rab33B/Atg16L1 effector complex.
Title: Crystal structure of the Rab33B/Atg16L1 effector complex.
Rab33 modulates autophagosome formation through interaction with Atg16L
Title: Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables G protein activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G protein activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in intra-Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in intra-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of constitutive secretory pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of constitutive secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to phagophore assembly site	IEA Inferred from Electronic Annotation more info
involved_in protein localization to phagophore assembly site	ISO Inferred from Sequence Orthology more info
involved_in protein localization to phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	IEA Inferred from Electronic Annotation more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi lumen	IEA Inferred from Electronic Annotation more info
located_in Golgi lumen	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-33B

Names: RAB33B, member of RAS oncogene family

NP_058554.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.