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Rab33b RAB33B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19338, updated on 8-Feb-2024

Summary

Official Symbol
Rab33bprovided by MGI
Official Full Name
RAB33B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1330805
See related
Ensembl:ENSMUSG00000027739 AllianceGenome:MGI:1330805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activity. Involved in autophagosome assembly. Located in Golgi lumen. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia. Orthologous to human RAB33B (RAB33B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.3), CNS E18 (RPKM 5.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rab33b in Genome Data Viewer
Location:
3 C; 3 22.49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51391387..51403649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51483966..51496228)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07614 Neighboring gene STARR-positive B cell enhancer ABC_E11182 Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene predicted gene, 50622 Neighboring gene N(alpha)-acetyltransferase 15, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E2664 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene predicted gene, 36008 Neighboring gene STARR-seq mESC enhancer starr_07615 Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51358072-51358308 Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:51363442-51363743

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of constitutive secretory pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi lumen ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-33B
Names
RAB33B, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016858.2NP_058554.1  ras-related protein Rab-33B

    See identical proteins and their annotated locations for NP_058554.1

    Status: VALIDATED

    Source sequence(s)
    AB004665, AC102860, BC065076
    Consensus CDS
    CCDS38427.1
    UniProtKB/Swiss-Prot
    O35963, Q3TWI8
    UniProtKB/TrEMBL
    Q0PD21, Q3TCY0
    Related
    ENSMUSP00000063054.7, ENSMUST00000054387.8
    Conserved Domains (1) summary
    cd04115
    Location:32201
    Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51391387..51403649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)