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SCAMP5 secretory carrier membrane protein 5 [ Homo sapiens (human) ]

Gene ID: 192683, updated on 17-Jun-2019

Summary

Official Symbol
SCAMP5provided by HGNC
Official Full Name
secretory carrier membrane protein 5provided by HGNC
Primary source
HGNC:HGNC:30386
See related
Ensembl:ENSG00000198794 MIM:613766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 81.6), duodenum (RPKM 16.5) and 6 other tissues See more
Orthologs

Genomic context

See SCAMP5 in Genome Data Viewer
Location:
15q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74995535..75021495)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75287876..75313836)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984731 Neighboring gene ribonuclease P and MRP subunit p25 Neighboring gene phosphopantothenoylcysteine decarboxylase Neighboring gene stromal cell derived factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24969, DKFZp686L1799

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
secretory carrier-associated membrane protein 5
Names
hSCAMP5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178111.2NP_001171582.1  secretory carrier-associated membrane protein 5

    See identical proteins and their annotated locations for NP_001171582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK127480, BC024700, DA810757
    Consensus CDS
    CCDS45306.1
    UniProtKB/Swiss-Prot
    Q8TAC9
    UniProtKB/TrEMBL
    A0A0A8K8F5
    Related
    ENSP00000355387.6, ENST00000361900.10
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family
  2. NM_001178112.2NP_001171583.1  secretory carrier-associated membrane protein 5

    See identical proteins and their annotated locations for NP_001171583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK056438, BC024700
    Consensus CDS
    CCDS45306.1
    UniProtKB/Swiss-Prot
    Q8TAC9
    UniProtKB/TrEMBL
    A0A0A8K8F5
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family
  3. NM_138967.4NP_620417.1  secretory carrier-associated membrane protein 5

    See identical proteins and their annotated locations for NP_620417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC024700, DA810757
    Consensus CDS
    CCDS45306.1
    UniProtKB/Swiss-Prot
    Q8TAC9
    UniProtKB/TrEMBL
    A0A0A8K8F5
    Related
    ENSP00000406547.3, ENST00000425597.8
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family

RNA

  1. NR_033660.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple exons in the 5' UTR and coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK301505, BC024700, DA810757

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74995535..75021495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720421.1XP_006720484.1  secretory carrier-associated membrane protein 5 isoform X2

    See identical proteins and their annotated locations for XP_006720484.1

    UniProtKB/Swiss-Prot
    Q8TAC9
    UniProtKB/TrEMBL
    A0A0A8K8F5
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family
  2. XM_006720422.3XP_006720485.1  secretory carrier-associated membrane protein 5 isoform X3

    See identical proteins and their annotated locations for XP_006720485.1

    UniProtKB/Swiss-Prot
    Q8TAC9
    Conserved Domains (1) summary
    pfam04144
    Location:44108
    SCAMP; SCAMP family
  3. XM_017021989.1XP_016877478.1  secretory carrier-associated membrane protein 5 isoform X3

    UniProtKB/Swiss-Prot
    Q8TAC9
    Conserved Domains (1) summary
    pfam04144
    Location:44108
    SCAMP; SCAMP family
  4. XM_006720420.1XP_006720483.1  secretory carrier-associated membrane protein 5 isoform X1

    Conserved Domains (1) summary
    pfam04144
    Location:24197
    SCAMP; SCAMP family
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