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Scamp5 secretory carrier membrane protein 5 [ Mus musculus (house mouse) ]

Gene ID: 56807, updated on 4-Dec-2022

Summary

Official Symbol
Scamp5provided by MGI
Official Full Name
secretory carrier membrane protein 5provided by MGI
Primary source
MGI:MGI:1928948
See related
Ensembl:ENSMUSG00000040722 AllianceGenome:MGI:1928948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sc5
Summary
This gene encodes a member of the Scamp (secretory carrier membrane protein) family. The encoded protein may be involved in neuronal vesicle trafficking. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Broad expression in cortex adult (RPKM 70.0), cerebellum adult (RPKM 68.8) and 25 other tissues See more
Orthologs
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Genomic context

See Scamp5 in Genome Data Viewer
Location:
9; 9 B
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57348610..57375343, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57441327..57468060, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene RIKEN cDNA 4930430J02 gene Neighboring gene phosphopantothenoylcysteine decarboxylase Neighboring gene DNA segment, Chr 9, Wayne State University 149 Neighboring gene fatty acid-binding protein, epidermal-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
secretory carrier-associated membrane protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301634.1NP_001288563.1  secretory carrier-associated membrane protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001288563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC125321, BC018613, CJ148246
    Consensus CDS
    CCDS40649.1
    UniProtKB/Swiss-Prot
    Q9JKD3
    UniProtKB/TrEMBL
    A0A6P7R9J7, A0A8C6GQ13
    Related
    ENSMUSP00000150867.2, ENSMUST00000214256.2
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family
  2. NM_001301635.1NP_001288564.1  secretory carrier-associated membrane protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the central coding region, which results in the use of an alternate start codon and a frameshift, compared to variant 1. The encoded isoform (2), has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC018613, CJ131214, CJ148246
    UniProtKB/Swiss-Prot
    Q9JKD3
    UniProtKB/TrEMBL
    A0A6P5Q4Z7
    Conserved Domains (1) summary
    pfam04144
    Location:44108
    SCAMP; SCAMP family
  3. NM_020270.3NP_064666.1  secretory carrier-associated membrane protein 5 isoform 1

    See identical proteins and their annotated locations for NP_064666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC018613, CJ148246
    Consensus CDS
    CCDS40649.1
    UniProtKB/Swiss-Prot
    Q9JKD3
    UniProtKB/TrEMBL
    A0A6P7R9J7, A0A8C6GQ13
    Related
    ENSMUSP00000035898.7, ENSMUST00000046587.8
    Conserved Domains (1) summary
    pfam04144
    Location:6179
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57348610..57375343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244475.2XP_030100335.1  secretory carrier-associated membrane protein 5 isoform X1

    Conserved Domains (1) summary
    pfam04144
    Location:107240
    SCAMP; SCAMP family