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Ptpra protein tyrosine phosphatase receptor type A [ Mus musculus (house mouse) ]

Gene ID: 19262, updated on 12-May-2024

Summary

Official Symbol
Ptpraprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Aprovided by MGI
Primary source
MGI:MGI:97808
See related
Ensembl:ENSMUSG00000027303 AllianceGenome:MGI:97808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptpa; Rptra; Ptpalpha; Rptpalpha; Rptralpha
Summary
Enables protein tyrosine phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; decidua; extraembryonic component; and future brain. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 35.2), CNS E18 (RPKM 33.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ptpra in Genome Data Viewer
Location:
2 F1; 2 63.23 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130292198..130396220)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130450278..130554300)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transmembrane 239 Neighboring gene PC-esterase domain containing 1A Neighboring gene STARR-positive B cell enhancer ABC_E11708 Neighboring gene VSP16 CORVET/HOPS core subunit Neighboring gene predicted gene, 52562 Neighboring gene VISTA enhancer mm1313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130358070-130358271 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130366029-130366233 Neighboring gene RIKEN cDNA 4930473A02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7863 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene oxytocin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118095

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase alpha
Names
LCA-related phosphatase
PTPTY-28
R-PTP-alpha
protein-tyrosine phosphatase alpha
NP_001157160.1
NP_001342090.1
NP_033006.2
XP_036015592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163688.1NP_001157160.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK010458, AK031690, AK162387
    Consensus CDS
    CCDS50712.1
    UniProtKB/TrEMBL
    Q91V35
    Related
    ENSMUSP00000028769.7, ENSMUST00000028769.14
    Conserved Domains (3) summary
    smart00194
    Location:523781
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:551781
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam07010
    Location:23170
    Endomucin; Endomucin
  2. NM_001355161.1NP_001342090.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL731707, BX890605
    Conserved Domains (3) summary
    smart00194
    Location:240500
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:560790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cl25495
    Location:17179
    Endomucin; Endomucin
  3. NM_008980.2NP_033006.2  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_033006.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK010458, AK031690, AK162387, AL731707
    Consensus CDS
    CCDS16743.1
    UniProtKB/Swiss-Prot
    A2AHF2, P18052, Q61808
    Related
    ENSMUSP00000076533.4, ENSMUST00000077303.4
    Conserved Domains (3) summary
    smart00194
    Location:559817
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:587817
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam07010
    Location:23170
    Endomucin; Endomucin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130292198..130396220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159699.1XP_036015592.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

    Conserved Domains (2) summary
    cd14621
    Location:250545
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:599826
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2