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Ptgs2 prostaglandin-endoperoxide synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 19225, updated on 27-Feb-2024

Summary

Official Symbol
Ptgs2provided by MGI
Official Full Name
prostaglandin-endoperoxide synthase 2provided by MGI
Primary source
MGI:MGI:97798
See related
Ensembl:ENSMUSG00000032487 AllianceGenome:MGI:97798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs
Summary
This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]
Expression
Biased expression in genital fat pad adult (RPKM 14.2), bladder adult (RPKM 2.2) and 6 other tissues See more
Orthologs
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Genomic context

See Ptgs2 in Genome Data Viewer
Location:
1 G1; 1 63.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (149975851..149983978)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (150100031..150108234)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02591 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02592 Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_02593 Neighboring gene STARR-seq mESC enhancer starr_02594 Neighboring gene predicted gene, 53591 Neighboring gene ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within anagen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to non-ionic osmotic stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cyclooxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cyclooxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cyclooxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo implantation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of platelet-derived growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuroinflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to nematode IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prostaglandin G/H synthase 2
Names
PGH synthase 2
cyclooxygenase-2
glucocorticoid-regulated inflammatory cyclooxygenase
macrophage activation-associated marker protein P71/73
prostaglandin H2 synthase 2
NP_035328.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011198.5NP_035328.2  prostaglandin G/H synthase 2 precursor

    See identical proteins and their annotated locations for NP_035328.2

    Status: VALIDATED

    Source sequence(s)
    AC114655
    Consensus CDS
    CCDS15353.1
    UniProtKB/Swiss-Prot
    Q05769, Q543K3
    UniProtKB/TrEMBL
    Q3UMR6
    Related
    ENSMUSP00000035065.8, ENSMUST00000035065.9
    Conserved Domains (2) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    149975851..149983978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)