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Prom2 prominin 2 [ Mus musculus (house mouse) ]

Gene ID: 192212, updated on 30-Apr-2024

Summary

Official Symbol
Prom2provided by MGI
Official Full Name
prominin 2provided by MGI
Primary source
MGI:MGI:2138997
See related
Ensembl:ENSMUSG00000027376 AllianceGenome:MGI:2138997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prom-rp
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; positive regulation of protein phosphorylation; and regulation of GTPase activity. Located in cell surface; plasma membrane; and prominosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and naris epithelium. Orthologous to human PROM2 (prominin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 207.3), bladder adult (RPKM 49.2) and 2 other tissues See more
Orthologs
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Genomic context

See Prom2 in Genome Data Viewer
Location:
2 F1; 2 62.04 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127368873..127383337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127526953..127541417, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 2A Neighboring gene STARR-positive B cell enhancer mm9_chr2:127279437-127279737 Neighboring gene Kv channel interacting protein 3, calsenilin Neighboring gene predicted gene, 35478 Neighboring gene predicted gene, 54151 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127385126-127385426 Neighboring gene predicted gene 14229 Neighboring gene zinc finger protein 661

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC31164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in microspike ISO
Inferred from Sequence Orthology
more info
 
located_in microspike ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in prominosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in prominosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prominin-2
Names
PROM-2
mPROML2
prominin-like protein 2
prominin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138750.2NP_620089.2  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620089.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029851, AK137749, CJ045574
    Consensus CDS
    CCDS16704.1
    UniProtKB/Swiss-Prot
    A2AHT1, Q3UUY6, Q8CDM5, Q8CHT5, Q8R4Y7, Q9WUC7
    Related
    ENSMUSP00000028855.8, ENSMUST00000028855.14
    Conserved Domains (1) summary
    pfam05478
    Location:29808
    Prominin; Prominin
  2. NM_178047.4NP_835148.2  prominin-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK029851, AK137749, BQ900846, CJ045574
    Consensus CDS
    CCDS50704.1
    UniProtKB/Swiss-Prot
    Q3UUY6
    Related
    ENSMUSP00000099503.3, ENSMUST00000103214.3
    Conserved Domains (1) summary
    pfam05478
    Location:29808
    Prominin; Prominin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127368873..127383337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)