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Prom2 prominin 2 [ Mus musculus (house mouse) ]

Gene ID: 192212, updated on 2-Nov-2024

Summary

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Official Symbol
Prom2provided by MGI
Official Full Name
prominin 2provided by MGI
Primary source
MGI:MGI:2138997
See related
Ensembl:ENSMUSG00000027376 AllianceGenome:MGI:2138997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prom-rp
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in negative regulation of endocytosis; positive regulation of cell projection organization; and positive regulation of protein phosphorylation. Located in cell surface; plasma membrane; and prominosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and naris epithelium. Orthologous to human PROM2 (prominin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 207.3), bladder adult (RPKM 49.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Prom2 in Genome Data Viewer
Location:
2 F1; 2 62.04 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127368873..127383337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127526953..127541417, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 2A Neighboring gene STARR-positive B cell enhancer mm9_chr2:127279437-127279737 Neighboring gene Kv channel interacting protein 3, calsenilin Neighboring gene predicted gene, 35478 Neighboring gene predicted gene, 54151 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127385126-127385426 Neighboring gene predicted gene 14229 Neighboring gene zinc finger protein 661

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice. Jászai J, et al. Histochem Cell Biol, 2007 Nov. PMID 17874118
  2. Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder. Jászai J, et al. Histochem Cell Biol, 2008 Oct. PMID 18536929
  3. Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney. Jászai J, et al. Histochem Cell Biol, 2010 May. PMID 20333396
  4. Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis. An J, et al. Mol Cell Biochem, 2024 Aug. PMID 37639200
  5. Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine. Florek M, et al. Cell Tissue Res, 2007 Apr. PMID 17109118

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis.
    Title: Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis.
  2. Data show the distribution and subcellular localization of prominin-2 within the kidney in situ.
    Title: Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney.
  3. Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract.
    Title: Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder.
  4. expression Prominin-2, in the three pairs of major salivary glands, i.e., submandibular-, major sublingual-, and parotid glands in adult mice.
    Title: Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice.
  5. These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions.
    Title: Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine.
  6. identification as well as molecular and cell biological characterization
    Title: Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of caveolin-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of pinocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in microspike ISO
Inferred from Sequence Orthology
more info
  
located_in microspike ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prominosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prominosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prominin-2
Names
PROM-2
mPROML2
prominin-like protein 2
prominin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138750.2 → NP_620089.2  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620089.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029851, AK137749, CJ045574
    Consensus CDS
    CCDS16704.1
    UniProtKB/Swiss-Prot
    A2AHT1, Q3UUY6, Q8CDM5, Q8CHT5, Q8R4Y7, Q9WUC7
    Related
    ENSMUSP00000028855.8, ENSMUST00000028855.14
    Conserved Domains (1) summary
    pfam05478
    Location:29 → 808
    Prominin; Prominin

  2. NM_178047.4 → NP_835148.2  prominin-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK029851, AK137749, BQ900846, CJ045574
    Consensus CDS
    CCDS50704.1
    UniProtKB/Swiss-Prot
    Q3UUY6
    Related
    ENSMUSP00000099503.3, ENSMUST00000103214.3
    Conserved Domains (1) summary
    pfam05478
    Location:29 → 808
    Prominin; Prominin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127368873..127383337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UUY6.1 GenPept UniProtKB/Swiss-Prot:Q3UUY6

Gene LinkOut

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