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PROM2 prominin 2 [ Homo sapiens (human) ]

Gene ID: 150696, updated on 18-Aug-2020

Summary

Official Symbol
PROM2provided by HGNC
Official Full Name
prominin 2provided by HGNC
Primary source
HGNC:HGNC:20685
See related
Ensembl:ENSG00000155066 MIM:617160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROML2
Summary
This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues See more
Orthologs

Genomic context

See PROM2 in Genome Data Viewer
Location:
2q11.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (95274449..95291320)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95939674..95966067)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 pseudogene 1 Neighboring gene zinc finger protein 570 pseudogene Neighboring gene potassium voltage-gated channel interacting protein 3 Neighboring gene fatty acid binding protein 7 pseudogene 2 Neighboring gene fumarylacetoacetate hydrolase domain containing 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ciliary membrane IEA
Inferred from Electronic Annotation
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microspike ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
prominosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prominosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
prominin-2
Names
prominin-like protein 2
prominin-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165977.3NP_001159449.1  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159449.1

    Status: REVIEWED

    Source sequence(s)
    AC009238, AF245304, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    Q8N271
    Related
    ENSP00000385716.2, ENST00000403131.6
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain
  2. NM_001165978.3NP_001159450.1  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159450.1

    Status: REVIEWED

    Source sequence(s)
    AC009238, AY358377, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    Q8N271
    Related
    ENSP00000318270.9, ENST00000317620.14
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain
  3. NM_001321070.2NP_001307999.1  prominin-2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009238, AI928825, BC025736, HY060111
    Conserved Domains (2) summary
    pfam05478
    Location:1461
    Prominin; Prominin
    cl15454
    Location:185335
    HrpJ; HrpJ-like domain
  4. NM_144707.4NP_653308.2  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653308.2

    Status: REVIEWED

    Source sequence(s)
    AF245303, AK290366, AK313267, BC025736, DB003233, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    Q8N271
    UniProtKB/TrEMBL
    B2R879
    Related
    ENSP00000318520.4, ENST00000317668.8
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    95274449..95291320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510672.2XP_011508974.1  prominin-2 isoform X1

    Conserved Domains (1) summary
    pfam05478
    Location:25476
    Prominin; Prominin
  2. XM_006712301.2XP_006712364.1  prominin-2 isoform X2

    See identical proteins and their annotated locations for XP_006712364.1

    Conserved Domains (2) summary
    pfam05478
    Location:1461
    Prominin; Prominin
    cl15454
    Location:185335
    HrpJ; HrpJ-like domain
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