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PROM2 prominin 2 [ Homo sapiens (human) ]

Gene ID: 150696, updated on 9-Jun-2025
Official Symbol
PROM2provided by HGNC
Official Full Name
prominin 2provided by HGNC
Primary source
HGNC:HGNC:20685
See related
Ensembl:ENSG00000155066 MIM:617160; AllianceGenome:HGNC:20685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROML2
Summary
This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues See more
Orthologs
NEW
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See PROM2 in Genome Data Viewer
Location:
2q11.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95274449..95291302)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95780925..95797779)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95940197..95957050)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16184 Neighboring gene solute carrier family 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11741 Neighboring gene zinc finger protein 892 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:95905736-95906935 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:95930712-95930896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95964228-95964728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95971889-95972774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95974547-95975430 Neighboring gene potassium voltage-gated channel interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95981486-95981986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95984379-95984880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95992523-95993090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996289-95996790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996791-95997290 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96008733-96008969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96040144-96040723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96041305-96041883 Neighboring gene fatty acid binding protein 7 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96047731-96047930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96051115-96052015 Neighboring gene uncharacterized LOC124907858

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC138714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in microspike ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in prominosome IEA
Inferred from Electronic Annotation
more info
 
located_in prominosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
prominin-2
Names
prominin-like protein 2
prominin-related protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165977.3NP_001159449.1  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159449.1

    Status: REVIEWED

    Source sequence(s)
    AC009238, AF245304, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
    UniProtKB/TrEMBL
    B2R879
    Related
    ENSP00000385716.2, ENST00000403131.6
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain
  2. NM_001165978.3NP_001159450.1  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159450.1

    Status: REVIEWED

    Source sequence(s)
    AC009238, AY358377, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
    UniProtKB/TrEMBL
    B2R879
    Related
    ENSP00000318270.9, ENST00000317620.14
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain
  3. NM_001321070.2NP_001307999.1  prominin-2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009238, AI928825, BC025736, HY060111
    Conserved Domains (1) summary
    pfam05478
    Location:1461
    Prominin
  4. NM_144707.4NP_653308.2  prominin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653308.2

    Status: REVIEWED

    Source sequence(s)
    AF245303, AK290366, AK313267, BC025736, DB003233, HY060111
    Consensus CDS
    CCDS2012.1
    UniProtKB/Swiss-Prot
    A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
    UniProtKB/TrEMBL
    B2R879
    Related
    ENSP00000318520.4, ENST00000317668.8
    Conserved Domains (2) summary
    pfam05478
    Location:25807
    Prominin; Prominin
    cl15454
    Location:531681
    HrpJ; HrpJ-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    95274449..95291302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443449.1XP_047299405.1  prominin-2 isoform X1

    UniProtKB/TrEMBL
    B2R879
  2. XM_011510672.3XP_011508974.1  prominin-2 isoform X2

    Conserved Domains (1) summary
    pfam05478
    Location:25476
    Prominin; Prominin
  3. XM_006712301.3XP_006712364.1  prominin-2 isoform X3

    See identical proteins and their annotated locations for XP_006712364.1

    Conserved Domains (1) summary
    pfam05478
    Location:1461
    Prominin

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791760.1 Reference GRCh38.p14 PATCHES

    Range
    36553..53406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332858.1XP_054188833.1  prominin-2 isoform X1

    UniProtKB/TrEMBL
    B2R879
  2. XM_054332859.1XP_054188834.1  prominin-2 isoform X2

  3. XM_054332860.1XP_054188835.1  prominin-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    95780925..95797779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340662.1XP_054196637.1  prominin-2 isoform X1

    UniProtKB/TrEMBL
    B2R879
  2. XM_054340663.1XP_054196638.1  prominin-2 isoform X2

  3. XM_054340664.1XP_054196639.1  prominin-2 isoform X3