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Bcas3 BCAS3 microtubule associated cell migration factor [ Mus musculus (house mouse) ]

Gene ID: 192197, updated on 8-Jan-2023

Summary

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Official Symbol
Bcas3provided by MGI
Official Full Name
BCAS3 microtubule associated cell migration factorprovided by MGI
Primary source
MGI:MGI:2385848
See related
Ensembl:ENSMUSG00000059439 AllianceGenome:MGI:2385848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K20D4; Phaf2; rudhira; 1500019F07Rik; 2610028P08Rik
Summary
Predicted to enable several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; positive regulation of cellular component organization; and regulation of GTPase activity. Located in cell leading edge; cell periphery; and cytoskeleton. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; genitourinary system; hemolymphoid system; and yolk sac. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 3.3), kidney adult (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bcas3 in Genome Data Viewer
Location:
11; 11 C
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85243611..85716884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85353110..85826058)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein (cytoplasmic tail) binding protein 2, opposite strand Neighboring gene protein phosphatase 1D magnesium-dependent, delta isoform Neighboring gene limb enhancer upstream of Tbx2 Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 1 Neighboring gene RIKEN cDNA 2610027K06 gene Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 2 Neighboring gene microRNA 5110 Neighboring gene Tbx2 5' regulatory region Neighboring gene VISTA enhancer mm1583 Neighboring gene T-box 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. Jain M, et al. Exp Cell Res, 2012 Apr 1. PMID 22300583
  2. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Siva K, et al. Gene Expr Patterns, 2006 Jan. PMID 16099728
  3. Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Shetty R, et al. Sci Rep, 2018 Apr 4. PMID 29618843, Free PMC Article
  4. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
  5. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expressed at high levels in embryonic stem cells and is restricted to blood islands and the erythroid lineage during embryonic development
    Title: Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCAS3 microtubule associated cell migration factor; breast carcinoma-amplified sequence 3 homolog
Names
breast carcinoma amplified sequence 3
protein rudhira

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166642.1 → NP_001160114.1  BCAS3 microtubule associated cell migration factor isoform b

    See identical proteins and their annotated locations for NP_001160114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.
    Source sequence(s)
    AK032423, BC060690, BX323026, BY116917, CN711546
    Consensus CDS
    CCDS48873.1
    UniProtKB/Swiss-Prot
    Q8CCN5
    UniProtKB/TrEMBL
    Q0VF62
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  2. NM_001166643.1 → NP_001160115.1  BCAS3 microtubule associated cell migration factor isoform b

    See identical proteins and their annotated locations for NP_001160115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.
    Source sequence(s)
    AL604024, BC060690, BC086693, BY116917
    Consensus CDS
    CCDS48873.1
    UniProtKB/TrEMBL
    Q0VF62
    Related
    ENSMUSP00000090496.4, ENSMUST00000092821.10
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  3. NM_138681.4 → NP_619622.3  BCAS3 microtubule associated cell migration factor isoform a

    See identical proteins and their annotated locations for NP_619622.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK032423, BC060690, BX323026, BY116917, CN711546
    Consensus CDS
    CCDS25195.1
    UniProtKB/Swiss-Prot
    Q8CCN5, Q9EPX3
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85243611..85716884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245680.2 → XP_030101540.1  breast carcinoma-amplified sequence 3 homolog isoform X1

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  2. XM_030245681.2 → XP_030101541.1  breast carcinoma-amplified sequence 3 homolog isoform X2

    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  3. XM_006532541.3 → XP_006532604.1  breast carcinoma-amplified sequence 3 homolog isoform X19

    See identical proteins and their annotated locations for XP_006532604.1

    UniProtKB/TrEMBL
    Q0VF62
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  4. XM_036156433.1 → XP_036012326.1  breast carcinoma-amplified sequence 3 homolog isoform X2

    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  5. XM_030245679.2 → XP_030101539.1  breast carcinoma-amplified sequence 3 homolog isoform X1

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  6. XM_036156436.1 → XP_036012329.1  breast carcinoma-amplified sequence 3 homolog isoform X11

    UniProtKB/TrEMBL
    B1AR74
    Related
    ENSMUSP00000103697.2, ENSMUST00000108062.8
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  7. XM_030245687.1 → XP_030101547.1  breast carcinoma-amplified sequence 3 homolog isoform X8

    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  8. XM_030245689.1 → XP_030101549.1  breast carcinoma-amplified sequence 3 homolog isoform X17

    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  9. XM_006532540.3 → XP_006532603.1  breast carcinoma-amplified sequence 3 homolog isoform X15

    See identical proteins and their annotated locations for XP_006532603.1

    UniProtKB/Swiss-Prot
    Q8CCN5, Q9EPX3
    Related
    ENSMUSP00000074416.5, ENSMUST00000074875.11
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  10. XM_030245685.2 → XP_030101545.1  breast carcinoma-amplified sequence 3 homolog isoform X5

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  11. XM_017314342.2 → XP_017169831.1  breast carcinoma-amplified sequence 3 homolog isoform X14

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  12. XM_030245688.1 → XP_030101548.1  breast carcinoma-amplified sequence 3 homolog isoform X12

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  13. XM_036156438.1 → XP_036012331.1  breast carcinoma-amplified sequence 3 homolog isoform X20

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  14. XM_030245678.2 → XP_030101538.1  breast carcinoma-amplified sequence 3 homolog isoform X1

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  15. XM_036156434.1 → XP_036012327.1  breast carcinoma-amplified sequence 3 homolog isoform X4

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  16. XM_030245684.2 → XP_030101544.1  breast carcinoma-amplified sequence 3 homolog isoform X2

    Conserved Domains (1) summary
    pfam12490
    Location:581 → 764
    BCAS3; Breast carcinoma amplified sequence 3

  17. XM_030245682.2 → XP_030101542.1  breast carcinoma-amplified sequence 3 homolog isoform X3

    Conserved Domains (1) summary
    pfam12490
    Location:534 → 762
    BCAS3; Breast carcinoma amplified sequence 3

  18. XM_011248810.4 → XP_011247112.1  breast carcinoma-amplified sequence 3 homolog isoform X21

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  19. XM_030245686.2 → XP_030101546.1  breast carcinoma-amplified sequence 3 homolog isoform X5

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

  20. XM_006532542.5 → XP_006532605.1  breast carcinoma-amplified sequence 3 homolog isoform X22

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  21. XM_006532537.5 → XP_006532600.1  breast carcinoma-amplified sequence 3 homolog isoform X7

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  22. XM_006532539.4 → XP_006532602.1  breast carcinoma-amplified sequence 3 homolog isoform X13

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  23. XM_006532536.5 → XP_006532599.1  breast carcinoma-amplified sequence 3 homolog isoform X6

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  24. XM_006532538.4 → XP_006532601.1  breast carcinoma-amplified sequence 3 homolog isoform X10

    Conserved Domains (1) summary
    pfam12490
    Location:594 → 777
    BCAS3; Breast carcinoma amplified sequence 3

  25. XM_036156435.1 → XP_036012328.1  breast carcinoma-amplified sequence 3 homolog isoform X9

    Conserved Domains (1) summary
    pfam12490
    Location:534 → 762
    BCAS3; Breast carcinoma amplified sequence 3

  26. XM_036156437.1 → XP_036012330.1  breast carcinoma-amplified sequence 3 homolog isoform X18

    Conserved Domains (1) summary
    pfam12490
    Location:534 → 762
    BCAS3; Breast carcinoma amplified sequence 3

  27. XM_017314343.1 → XP_017169832.1  breast carcinoma-amplified sequence 3 homolog isoform X16

    Conserved Domains (1) summary
    pfam12490
    Location:534 → 762
    BCAS3; Breast carcinoma amplified sequence 3

  28. XM_036156439.1 → XP_036012332.1  breast carcinoma-amplified sequence 3 homolog isoform X20

    Conserved Domains (1) summary
    pfam12490
    Location:521 → 749
    BCAS3; Breast carcinoma amplified sequence 3

RNA

  1. XR_001779924.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCN5.2 GenPept UniProtKB/Swiss-Prot:Q8CCN5

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