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Ptgds prostaglandin D2 synthase (brain) [ Mus musculus (house mouse) ]

Gene ID: 19215, updated on 17-Jan-2023

Summary

Official Symbol
Ptgdsprovided by MGI
Official Full Name
prostaglandin D2 synthase (brain)provided by MGI
Primary source
MGI:MGI:99261
See related
Ensembl:ENSMUSG00000015090 AllianceGenome:MGI:99261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGD2; PGDS; 21kDa; PGDS2; Ptgs3; L-PGDS
Summary
Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within negative regulation of male germ cell proliferation. Located in extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 446.8), frontal lobe adult (RPKM 410.4) and 5 other tissues See more
Orthologs
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Genomic context

See Ptgds in Genome Data Viewer
Location:
2 A3; 2 17.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25356721..25360141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25466709..25470110, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 2 Neighboring gene microRNA 3087 Neighboring gene non-homologous end joining factor Neighboring gene chloride intracellular channel 3 Neighboring gene predicted gene, 35287 Neighboring gene lipocalin 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables prostaglandin-D synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables retinoid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoid binding ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prostaglandin-H2 D-isomerase
Names
PGD2 synthase
glutathione-independent PGD synthase
glutathione-independent PGD synthetase
lipocalin-type prostaglandin-D synthase
prostaglandin D2 synthase (21 kDa, brain)
prostaglandin-D2 synthase
NP_032989.2
XP_006497849.1
XP_006497850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008963.3NP_032989.2  prostaglandin-H2 D-isomerase precursor

    See identical proteins and their annotated locations for NP_032989.2

    Status: VALIDATED

    Source sequence(s)
    AL732557
    Consensus CDS
    CCDS38074.1
    UniProtKB/Swiss-Prot
    O09114, Q62169
    Related
    ENSMUSP00000015234.7, ENSMUST00000015234.13
    Conserved Domains (1) summary
    cd19419
    Location:30188
    lipocalin_L-PGDS; lipocalin-type prostaglandin D synthase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25356721..25360141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497787.4XP_006497850.1  prostaglandin-H2 D-isomerase isoform X1

    See identical proteins and their annotated locations for XP_006497850.1

    UniProtKB/Swiss-Prot
    O09114, Q62169
    Conserved Domains (1) summary
    cd19419
    Location:30188
    lipocalin_L-PGDS; lipocalin-type prostaglandin D synthase
  2. XM_006497786.5XP_006497849.1  prostaglandin-H2 D-isomerase isoform X1

    See identical proteins and their annotated locations for XP_006497849.1

    UniProtKB/Swiss-Prot
    O09114, Q62169
    Related
    ENSMUSP00000109889.2, ENSMUST00000114251.8
    Conserved Domains (1) summary
    cd19419
    Location:30188
    lipocalin_L-PGDS; lipocalin-type prostaglandin D synthase