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PTGDS prostaglandin D2 synthase [ Homo sapiens (human) ]

Gene ID: 5730, updated on 17-Apr-2020

Summary

Official Symbol
PTGDSprovided by HGNC
Official Full Name
prostaglandin D2 synthaseprovided by HGNC
Primary source
HGNC:HGNC:9592
See related
Ensembl:ENSG00000107317 MIM:176803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues See more
Orthologs

Genomic context

See PTGDS in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136977504..136981742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139871898..139876194)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 12 Neighboring gene long intergenic non-protein coding RNA 2692 Neighboring gene lipocalin like 1 Neighboring gene PAXX non-homologous end joining factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
NHGRI GWA Catalog
Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA increases PTGDS mRNA expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LCNL1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin-D synthase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian sleep/wake cycle, sleep ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostaglandin-H2 D-isomerase
Names
PGD2 synthase
beta-trace protein
cerebrin-28
glutathione-independent PGD synthase
glutathione-independent PGD synthetase
lipocalin-type prostaglandin D synthase
prostaglandin D synthase
prostaglandin D2 synthase 21kDa (brain)
testis tissue sperm-binding protein Li 63n
NP_000945.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000954.6NP_000945.3  prostaglandin-H2 D-isomerase precursor

    See identical proteins and their annotated locations for NP_000945.3

    Status: REVIEWED

    Source sequence(s)
    AL807752
    Consensus CDS
    CCDS7019.1
    UniProtKB/Swiss-Prot
    P41222
    UniProtKB/TrEMBL
    A0A024R8G3
    Related
    ENSP00000360687.3, ENST00000371625.8
    Conserved Domains (1) summary
    pfam00061
    Location:40184
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136977504..136981742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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