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PTGDS prostaglandin D2 synthase [ Homo sapiens (human) ]

Gene ID: 5730, updated on 7-Dec-2018

Summary

Official Symbol
PTGDSprovided by HGNC
Official Full Name
prostaglandin D2 synthaseprovided by HGNC
Primary source
HGNC:HGNC:9592
See related
Ensembl:ENSG00000107317 MIM:176803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues See more
Orthologs

Genomic context

See PTGDS in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (136977504..136981742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139871898..139876194)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 12 Neighboring gene proline rich 31 Neighboring gene lipocalin like 1 Neighboring gene PAXX, non-homologous end joining factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
NHGRI GWA Catalog
Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA increases PTGDS mRNA expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • C20 prostanoid biosynthesis, organism-specific biosystem (from BIOCYC)
    C20 prostanoid biosynthesis, organism-specific biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
  • C20 prostanoid biosynthesis, conserved biosystem (from BIOCYC)
    C20 prostanoid biosynthesis, conserved biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
  • Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystem (from REACTOME)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystemThe bioactive prostaglandin (PG) signalling molecules, including PGA2, PGE2, PGF2a, and PGI2 (prostacyclin) are synthesised from arachidonic acid and its products by various prostaglandin synthase ty...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LCNL1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin-D synthase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian sleep/wake cycle, sleep ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostaglandin-H2 D-isomerase
Names
PGD2 synthase
beta-trace protein
cerebrin-28
glutathione-independent PGD synthase
glutathione-independent PGD synthetase
lipocalin-type prostaglandin D synthase
prostaglandin D synthase
prostaglandin D2 synthase 21kDa (brain)
testis tissue sperm-binding protein Li 63n
NP_000945.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000954.6NP_000945.3  prostaglandin-H2 D-isomerase precursor

    See identical proteins and their annotated locations for NP_000945.3

    Status: REVIEWED

    Source sequence(s)
    AL807752
    Consensus CDS
    CCDS7019.1
    UniProtKB/Swiss-Prot
    P41222
    UniProtKB/TrEMBL
    A0A024R8G3
    Related
    ENSP00000360687.3, ENST00000371625.7
    Conserved Domains (1) summary
    pfam00061
    Location:40184
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    136977504..136981742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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