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Dicer1 dicer 1, ribonuclease type III [ Mus musculus (house mouse) ]

Gene ID: 192119, updated on 26-Oct-2020

Summary

Official Symbol
Dicer1provided by MGI
Official Full Name
dicer 1, ribonuclease type IIIprovided by MGI
Primary source
MGI:MGI:2177178
See related
Ensembl:ENSMUSG00000041415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dice; D12Ertd7; D12Ertd7e; mKIAA0928; 1110006F08Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), CNS E14 (RPKM 8.7) and 28 other tissues See more
Orthologs

Genomic context

See Dicer1 in Genome Data Viewer
Location:
12 E; 12 54.83 cM
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104653999..104718227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104687740..104751968, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105925952..105990162, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568012 Neighboring gene predicted gene, 31573 Neighboring gene calmin Neighboring gene uncharacterized LOC118568013 Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene predicted gene, 31742

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
endoribonuclease activity, producing 5'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
ribonuclease III activity ISA
Inferred from Sequence Alignment
more info
PubMed 
ribonuclease III activity ISO
Inferred from Sequence Orthology
more info
 
siRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic ISO
Inferred from Sequence Orthology
more info
 
RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
RNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
anatomical structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac neural crest cell development involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
conversion of ds siRNA to ss siRNA ISO
Inferred from Sequence Orthology
more info
 
conversion of ds siRNA to ss siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
hair follicle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal epithelial cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA loading onto RISC involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast differentiation involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory bulb interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pericentric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
production of siRNA involved in RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
production of siRNA involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
production of siRNA involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of Notch signaling pathway IC
Inferred by Curator
more info
PubMed 
regulation of RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of enamel mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
reproductive structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
siRNA loading onto RISC involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
spermatogonial cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
targeting of mRNA for destruction involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
trophectodermal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tube formation ISO
Inferred from Sequence Orthology
more info
 
zygote asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoribonuclease Dicer
Names
Dicer1, Dcr-1 homolog
double-strand-specific ribonuclease mDCR-1
NP_683750.2
XP_006515671.1
XP_006515672.1
XP_006515674.1
XP_017170486.1
XP_017170487.1
XP_017170488.1
XP_036013153.1
XP_036013154.1
XP_036013155.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148948.2NP_683750.2  endoribonuclease Dicer

    See identical proteins and their annotated locations for NP_683750.2

    Status: VALIDATED

    Source sequence(s)
    AC124364
    Consensus CDS
    CCDS36539.1
    UniProtKB/TrEMBL
    F8VQ54
    Related
    ENSMUSP00000043676.6, ENSMUST00000041987.6
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104653999..104718227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314997.2XP_017170486.1  endoribonuclease Dicer isoform X4

  2. XM_017314999.3XP_017170488.1  endoribonuclease Dicer isoform X6

    Conserved Domains (5) summary
    smart00535
    Location:803894
    RIBOc; Ribonuclease III family
    COG0571
    Location:11671419
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:393515
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cl38915
    Location:171
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    pfam03368
    Location:137225
    Dicer_dimer; Dicer dimerization domain
  3. XM_006515611.4XP_006515674.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515674.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  4. XM_036157262.1XP_036013155.1  endoribonuclease Dicer isoform X3

  5. XM_006515608.4XP_006515671.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515671.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  6. XM_036157260.1XP_036013153.1  endoribonuclease Dicer isoform X2

  7. XM_017314998.3XP_017170487.1  endoribonuclease Dicer isoform X5

    Conserved Domains (7) summary
    smart00535
    Location:11471238
    RIBOc; Ribonuclease III family
    COG0571
    Location:15111763
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:737859
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:122216
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:223415
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    pfam03368
    Location:481569
    Dicer_dimer; Dicer dimerization domain
    cl28899
    Location:190
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  8. XM_036157261.1XP_036013154.1  endoribonuclease Dicer isoform X2

  9. XM_006515609.4XP_006515672.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515672.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
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