U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dicer1 dicer 1, ribonuclease type III [ Mus musculus (house mouse) ]

Gene ID: 192119, updated on 28-Jun-2022

Summary

Official Symbol
Dicer1provided by MGI
Official Full Name
dicer 1, ribonuclease type IIIprovided by MGI
Primary source
MGI:MGI:2177178
See related
Ensembl:ENSMUSG00000041415 AllianceGenome:MGI:2177178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
aviD; D12Ertd7e; mKIAA0928; 1110006F08Rik
Summary
Enables miRNA binding activity and ribonuclease III activity. Involved in several processes, including meiotic spindle organization; nervous system development; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; negative regulation of macromolecule metabolic process; and regulation of nervous system development. Located in cytoplasm. Part of RISC complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study DiGeorge syndrome and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), CNS E14 (RPKM 8.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dicer1 in Genome Data Viewer
Location:
12 E; 12 54.83 cM
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104653999..104718227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104687740..104751968, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105925952..105990162, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53760 Neighboring gene predicted gene, 31573 Neighboring gene calmin Neighboring gene predicted gene, 53761 Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene predicted gene, 31742

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables endoribonuclease activity, producing 5'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonuclease III activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables ribonuclease III activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonuclease III activity TAS
Traceable Author Statement
more info
 
enables siRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in RISC complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within RNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
involved_in global gene silencing by mRNA cleavage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intestinal epithelial cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory bulb interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pericentric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatic stellate cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional gene silencing by RNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Notch signaling pathway IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within regulation of RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of enamel mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within siRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in siRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogonial cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trophectodermal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within zygote asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoribonuclease Dicer
Names
Dicer1, Dcr-1 homolog
double-strand-specific ribonuclease mDCR-1
NP_683750.2
XP_006515671.1
XP_006515672.1
XP_006515674.1
XP_017170486.1
XP_017170487.1
XP_017170488.1
XP_036013153.1
XP_036013154.1
XP_036013155.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148948.2NP_683750.2  endoribonuclease Dicer

    See identical proteins and their annotated locations for NP_683750.2

    Status: VALIDATED

    Source sequence(s)
    AC124364
    Consensus CDS
    CCDS36539.1
    UniProtKB/TrEMBL
    F8VQ54
    Related
    ENSMUSP00000043676.8, ENSMUST00000041987.8
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104653999..104718227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314997.2XP_017170486.1  endoribonuclease Dicer isoform X4

    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    cd00593
    Location:16661751
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  2. XM_017314999.3XP_017170488.1  endoribonuclease Dicer isoform X6

    Conserved Domains (5) summary
    smart00535
    Location:803894
    RIBOc; Ribonuclease III family
    COG0571
    Location:11671419
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:393515
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cl38915
    Location:171
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    pfam03368
    Location:137225
    Dicer_dimer; Dicer dimerization domain
  3. XM_006515611.4XP_006515674.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515674.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  4. XM_036157262.1XP_036013155.1  endoribonuclease Dicer isoform X3

    Conserved Domains (7) summary
    COG0571
    Location:15981850
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00593
    Location:12861348
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  5. XM_006515608.4XP_006515671.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515671.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain
  6. XM_036157260.1XP_036013153.1  endoribonuclease Dicer isoform X2

    Conserved Domains (7) summary
    smart00535
    Location:12661357
    RIBOc; Ribonuclease III family
    COG0571
    Location:16301882
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:856978
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:241335
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:342534
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:19209
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:600688
    Dicer_dimer; Dicer dimerization domain
  7. XM_017314998.3XP_017170487.1  endoribonuclease Dicer isoform X5

    Conserved Domains (7) summary
    smart00535
    Location:11471238
    RIBOc; Ribonuclease III family
    COG0571
    Location:15111763
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:737859
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:122216
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:223415
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    pfam03368
    Location:481569
    Dicer_dimer; Dicer dimerization domain
    cl28899
    Location:190
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  8. XM_036157261.1XP_036013154.1  endoribonuclease Dicer isoform X2

    Conserved Domains (7) summary
    smart00535
    Location:12661357
    RIBOc; Ribonuclease III family
    COG0571
    Location:16301882
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:856978
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:241335
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:342534
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:19209
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:600688
    Dicer_dimer; Dicer dimerization domain
  9. XM_006515609.4XP_006515672.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_006515672.1

    UniProtKB/TrEMBL
    F8VQ54
    Conserved Domains (7) summary
    smart00535
    Location:12861377
    RIBOc; Ribonuclease III family
    COG0571
    Location:16501902
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:876998
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:261355
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:362554
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:32229
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:620708
    Dicer_dimer; Dicer dimerization domain