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DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ]

Gene ID: 23405, updated on 18-Nov-2018

Summary

Official Symbol
DICER1provided by HGNC
Official Full Name
dicer 1, ribonuclease IIIprovided by HGNC
Primary source
HGNC:HGNC:17098
See related
Ensembl:ENSG00000100697 MIM:606241; Vega:OTTHUMG00000166134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
Summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See DICER1 in Genome Data Viewer
Location:
14q32.13
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (95086228..95158263, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95623759, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984646 Neighboring gene long intergenic non-protein coding RNA 2279 Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene calmin Neighboring gene uncharacterized LOC105370637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2017-04-13)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2017-04-13)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed
gag Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
    Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • Hypoxia-mediated EMT and Stemness, organism-specific biosystem (from WikiPathways)
    Hypoxia-mediated EMT and Stemness, organism-specific biosystemModel of hypoxia mediated EMT and stemness.
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • RNA interference, organism-specific biosystem (from WikiPathways)
    RNA interference, organism-specific biosystemThe process of RNA-interference in eukaryotic cells. Long precursor microRNA (miRNA), called pri-miRNA, is cleaved by RNase III endonuclease (Drosha) into pieces of approximately 70 nucleotides each ...
  • Small interfering RNA (siRNA) biogenesis, organism-specific biosystem (from REACTOME)
    Small interfering RNA (siRNA) biogenesis, organism-specific biosystemSmall interfering RNAs (siRNAs) are 21-25 nucleotide single-stranded RNAs produced by cleavage of longer double-stranded RNAs by the enzyme DICER1 within the RISC loading complex containing DICER1, a...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • miRNA Biogenesis, organism-specific biosystem (from WikiPathways)
    miRNA Biogenesis, organism-specific biosystemmicroRNA biogenesis + an example of a miRBase entry. As an example immature hsa-mir-146a is shown

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoribonuclease activity TAS
Traceable Author Statement
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease III activity EXP
Inferred from Experiment
more info
PubMed 
ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
siRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
conversion of ds siRNA to ss siRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
conversion of ds siRNA to ss siRNA involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA loading onto RISC involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
miRNA metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
peripheral nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Schwann cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
production of siRNA involved in RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
production of siRNA involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
production of siRNA involved in RNA interference TAS
Traceable Author Statement
more info
 
siRNA loading onto RISC involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
targeting of mRNA for destruction involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
ARC complex IC
Inferred by Curator
more info
PubMed 
RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
micro-ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
endoribonuclease Dicer
Names
Dicer1, Dcr-1 homolog
dicer 1, double-stranded RNA-specific endoribonuclease
dicer 1, ribonuclease type III
helicase MOI
helicase with RNAse motif
NP_001182502.1
NP_001258211.1
NP_001278557.1
NP_085124.2
NP_803187.1
XP_011534901.1
XP_011534902.1
XP_011534903.1
XP_011534904.1
XP_011534906.1
XP_011534907.1
XP_016876609.1
XP_016876610.1
XP_016876611.1
XP_016876612.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016311.1 RefSeqGene

    Range
    4413..76195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

mRNA and Protein(s)

  1. NM_001195573.1NP_001182502.1  endoribonuclease Dicer isoform 2

    See identical proteins and their annotated locations for NP_001182502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL356017, AL390254, HM595745
    Consensus CDS
    CCDS55941.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000444719.1, OTTHUMP00000274912, ENST00000541352.5, OTTHUMT00000474215
    Conserved Domains (10) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    COG0571
    Location:16661765
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:16821767
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:445553
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:631714
    Dicer_dimer; Dicer dimerization domain
  2. NM_001271282.2NP_001258211.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_001258211.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000435681.1, OTTHUMP00000231972, ENST00000527414.5, OTTHUMT00000387999
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  3. NM_001291628.1NP_001278557.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_001278557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845868, BM152875
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  4. NM_030621.4NP_085124.2  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_085124.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845867, BM152875
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000437256.1, OTTHUMP00000231971, ENST00000526495.5, OTTHUMT00000387997
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  5. NM_177438.2NP_803187.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_803187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AL390254, BC150287
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000343745.3, OTTHUMP00000231970, ENST00000343455.7, OTTHUMT00000387996
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    95086228..95158263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021121.2XP_016876610.1  endoribonuclease Dicer isoform X1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  2. XM_011536600.3XP_011534902.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534902.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  3. XM_011536599.2XP_011534901.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534901.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  4. XM_011536601.3XP_011534903.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534903.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  5. XM_011536602.3XP_011534904.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534904.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  6. XM_017021120.2XP_016876609.1  endoribonuclease Dicer isoform X1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  7. XM_017021122.2XP_016876611.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
  8. XM_011536604.2XP_011534906.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
  9. XM_011536605.2XP_011534907.1  endoribonuclease Dicer isoform X3

    Conserved Domains (7) summary
    smart00535
    Location:803894
    RIBOc; Ribonuclease III family
    smart00358
    Location:13571420
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:11731425
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00593
    Location:11891353
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:393515
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam00271
    Location:860
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:138221
    Dicer_dimer; Dicer dimerization domain
  10. XM_017021123.2XP_016876612.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
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