Format

Send to:

Choose Destination

DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ]

Gene ID: 23405, updated on 31-Jul-2021

Summary

Official Symbol
DICER1provided by HGNC
Official Full Name
dicer 1, ribonuclease IIIprovided by HGNC
Primary source
HGNC:HGNC:17098
See related
Ensembl:ENSG00000100697 MIM:606241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCR1; GLOW; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
Summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DICER1 in Genome Data Viewer
Location:
14q32.13
Exon count:
34
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (95086228..95158263, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95624347, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984646 Neighboring gene long intergenic non-protein coding RNA 2279 Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene calmin Neighboring gene uncharacterized LOC105370637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
DICER1-related pleuropulmonary blastoma cancer predisposition syndrome
MedGen: C3839822 OMIM: 601200 GeneReviews: DICER1 Tumor Predisposition
Compare labs
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
GeneReviews: Not available
Genome-wide association of lipid-lowering response to statins in combined study populations.
GeneReviews: Not available
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
MedGen: C4748924 OMIM: 618272 GeneReviews: Not available
Compare labs
Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors
MedGen: C0302859 OMIM: 138800 GeneReviews: DICER1 Tumor Predisposition
Compare labs
Rhabdomyosarcoma, embryonal, 2
MedGen: C1867234 OMIM: 180295 GeneReviews: DICER1 Tumor Predisposition
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2017-04-13)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2017-04-13)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed
gag Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endoribonuclease activity TAS
Traceable Author Statement
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease III activity EXP
Inferred from Experiment
more info
PubMed 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonuclease III activity TAS
Traceable Author Statement
more info
 
enables siRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in conversion of ds siRNA to ss siRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in conversion of ds siRNA to ss siRNA involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA loading onto RISC involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA metabolic process TAS
Traceable Author Statement
more info
 
involved_in negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peripheral nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Schwann cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in production of miRNAs involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in production of miRNAs involved in gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in production of siRNA involved in RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in production of siRNA involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
involved_in production of siRNA involved in RNA interference TAS
Traceable Author Statement
more info
 
involved_in siRNA loading onto RISC involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA catabolic process TAS
Traceable Author Statement
more info
 
involved_in targeting of mRNA for destruction involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ARC complex IC
Inferred by Curator
more info
PubMed 
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoribonuclease Dicer
Names
Dicer1, Dcr-1 homolog
dicer 1, double-stranded RNA-specific endoribonuclease
dicer 1, ribonuclease type III
helicase MOI
helicase with RNAse motif
NP_001182502.1
NP_001258211.1
NP_001278557.1
NP_085124.2
NP_803187.1
XP_011534901.1
XP_011534902.1
XP_011534903.1
XP_011534904.1
XP_011534906.1
XP_011534907.1
XP_016876609.1
XP_016876610.1
XP_016876611.1
XP_016876612.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016311.1 RefSeqGene

    Range
    4413..76195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

mRNA and Protein(s)

  1. NM_001195573.1NP_001182502.1  endoribonuclease Dicer isoform 2

    See identical proteins and their annotated locations for NP_001182502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL356017, AL390254, HM595745
    Consensus CDS
    CCDS55941.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000444719.1, ENST00000541352.5
    Conserved Domains (10) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    COG0571
    Location:16661765
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:16821767
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:445553
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:631714
    Dicer_dimer; Dicer dimerization domain
  2. NM_001271282.3NP_001258211.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_001258211.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000435681.1, ENST00000527414.5
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  3. NM_001291628.2NP_001278557.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_001278557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845868, BM152875
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  4. NM_001395677.1NP_001382606.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  5. NM_001395678.1NP_001382607.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  6. NM_001395679.1NP_001382608.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  7. NM_001395680.1NP_001382609.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  8. NM_001395681.1NP_001382610.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  9. NM_001395682.1NP_001382611.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  10. NM_001395683.1NP_001382612.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  11. NM_001395684.1NP_001382613.1  endoribonuclease Dicer isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  12. NM_001395685.1NP_001382614.1  endoribonuclease Dicer isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  13. NM_001395686.1NP_001382615.1  endoribonuclease Dicer isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  14. NM_001395687.1NP_001382616.1  endoribonuclease Dicer isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  15. NM_001395688.1NP_001382617.1  endoribonuclease Dicer isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  16. NM_001395689.1NP_001382618.1  endoribonuclease Dicer isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  17. NM_001395691.1NP_001382620.1  endoribonuclease Dicer isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  18. NM_001395692.1NP_001382621.1  endoribonuclease Dicer isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  19. NM_001395693.1NP_001382622.1  endoribonuclease Dicer isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  20. NM_001395694.1NP_001382623.1  endoribonuclease Dicer isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  21. NM_001395695.1NP_001382624.1  endoribonuclease Dicer isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  22. NM_001395696.1NP_001382625.1  endoribonuclease Dicer isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  23. NM_001395697.1NP_001382626.1  endoribonuclease Dicer isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  24. NM_001395698.1NP_001382627.1  endoribonuclease Dicer isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL356017
  25. NM_001395699.1NP_001382628.1  endoribonuclease Dicer isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL356017
  26. NM_001395700.1NP_001382629.1  endoribonuclease Dicer isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL356017
  27. NM_030621.4NP_085124.2  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_085124.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845867, BM152875
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000437256.1, ENST00000526495.6
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  28. NM_177438.3NP_803187.1  endoribonuclease Dicer isoform 1

    See identical proteins and their annotated locations for NP_803187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AB023145, AL356017, AL390254
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000343745.3, ENST00000343455.8
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain

RNA

  1. NR_172715.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  2. NR_172716.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  3. NR_172717.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  4. NR_172718.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  5. NR_172719.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254
  6. NR_172720.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356017, AL390254

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    95086228..95158263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021121.2XP_016876610.1  endoribonuclease Dicer isoform X1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  2. XM_011536600.3XP_011534902.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534902.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  3. XM_011536599.2XP_011534901.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534901.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000376783.1, ENST00000393063.6
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  4. XM_011536601.3XP_011534903.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534903.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  5. XM_011536602.3XP_011534904.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_011534904.1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  6. XM_017021120.2XP_016876609.1  endoribonuclease Dicer isoform X1

    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (7) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    cd18802
    Location:372564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerization domain
  7. XM_017021122.2XP_016876611.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
  8. XM_011536604.2XP_011534906.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
  9. XM_011536605.2XP_011534907.1  endoribonuclease Dicer isoform X3

    Conserved Domains (7) summary
    smart00535
    Location:803894
    RIBOc; Ribonuclease III family
    smart00358
    Location:13571420
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:11731425
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00593
    Location:11891353
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:393515
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam00271
    Location:860
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:138221
    Dicer_dimer; Dicer dimerization domain
  10. XM_017021123.2XP_016876612.1  endoribonuclease Dicer isoform X2

    Conserved Domains (9) summary
    smart00535
    Location:11611252
    RIBOc; Ribonuclease III family
    smart00358
    Location:17151778
    DSRM; Double-stranded RNA binding motif
    COG0571
    Location:15311783
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:1274
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:15471711
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:751873
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:136230
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00271
    Location:310418
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:496579
    Dicer_dimer; Dicer dimerization domain
Support Center