Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psme3provided by MGI
Official Full Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)provided by MGI
Primary source: MGI:MGI:1096366
See related: Ensembl:ENSMUSG00000078652 AllianceGenome:MGI:1096366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ki; pa28g; REGgamma; PA28gamma
Summary: Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S transition of mitotic cell cycle; and regulation of proteolysis. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 81.8), liver E14 (RPKM 74.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 64.67 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101206090..101214363)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101316213..101323537)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Title: REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Loss of PA28gamma exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice.
Title: Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice.
Aging-associated REGgamma proteasome decline predisposes to tauopathy.
Title: Aging-associated REGγ proteasome decline predisposes to tauopathy.
11S Proteasome Activator REGgamma Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway.
Title: 11S Proteasome Activator REGγ Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway.
Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis.
Title: Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis.
REGgamma controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells.
Title: REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells.
REGgamma regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
Title: REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
The proteasome activator REGgamma counteracts immunoproteasome expression and autoimmunity.
Title: The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity.
The results of the present study also indicated that all of the effects of the miR1955p inhibitor on ATDC5 cells were reversed by REGgamma silencing. The results also revealed that a miR1955p inhibitor inhibited the LPS induced repression of the Wnt/betacatenin signaling pathway and activation of nuclear factor (NF)kappaB signaling pathway in ATDC5 cells.
Title: MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ.
REGgamma regulates NFkappaB activity by specifically degrading IkBepsilon to regulate inflammation in testicular Leydig cells.
Title: Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125921 (e-PCR)
- UniSTS:162638

Psme3 (e-PCR), detects polymorphism
- UniSTS:144283

RH136343 (e-PCR)
- UniSTS:210333

RH124923 (e-PCR)
- UniSTS:161745

RH129153 (e-PCR)
- UniSTS:212461

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables MDM2/MDM4 family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activator activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome activator complex subunit 3

Names: 11S regulator complex subunit gamma; REG-gamma; activator of multicatalytic protease subunit 3; ki nuclear autoantigen; proteaseome (prosome, macropain) 28 subunit, 3; proteasome activator 28 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011192.4 → NP_035322.1 proteasome activator complex subunit 3

See identical proteins and their annotated locations for NP_035322.1

Status: VALIDATED

Source sequence(s)

AK140597, AW490477, BF456075, BY324327

Consensus CDS

CCDS25463.1

UniProtKB/Swiss-Prot

P61290

UniProtKB/TrEMBL

Q4FK54

Related

ENSMUSP00000019470.8, ENSMUST00000019470.14

Conserved Domains (2) summary

pfam02251
Location:9 → 69

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:109 → 251

PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101206090..101214363

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156432.1 → XP_036012325.1 proteasome activator complex subunit 3 isoform X3

Conserved Domains (2) summary

pfam02251
Location:9 → 46

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:74 → 216

PA28_beta; Proteasome activator pa28 beta subunit
XM_030245676.1 → XP_030101536.1 proteasome activator complex subunit 3 isoform X1

Conserved Domains (2) summary

pfam02251
Location:25 → 80

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:119 → 263

PA28_beta; Proteasome activator pa28 beta subunit
XM_036156431.1 → XP_036012324.1 proteasome activator complex subunit 3 isoform X2

Conserved Domains (2) summary

pfam02251
Location:25 → 67

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:85 → 227

PA28_beta; Proteasome activator pa28 beta subunit