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Psmb10 proteasome (prosome, macropain) subunit, beta type 10 [ Mus musculus (house mouse) ]

Gene ID: 19171, updated on 8-Dec-2022

Summary

Official Symbol
Psmb10provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 10provided by MGI
Primary source
MGI:MGI:1096380
See related
Ensembl:ENSMUSG00000031897 AllianceGenome:MGI:1096380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mecl1; Mecl-1
Summary
Predicted to enable threonine-type endopeptidase activity. Acts upstream of or within T cell proliferation and cell morphogenesis. Part of proteasome core complex and spermatoproteasome complex. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; hemolymphoid system; and liver. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 146.6), large intestine adult (RPKM 133.0) and 22 other tissues See more
Orthologs
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Genomic context

See Psmb10 in Genome Data Viewer
Location:
8 D3; 8 53.06 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106662360..106665024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105935728..105938392, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene protein serine kinase H1 Neighboring gene chymotrypsin-like Neighboring gene lecithin cholesterol acyltransferase Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spermatoproteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-10
Names
low molecular mass protein 10
macropain subunit MECl-1
multicatalytic endopeptidase complex subunit MECl-1
prosome Mecl1
proteasome (prosomome, macropain) subunit, beta type 10
proteasome MECl-1
proteasome subunit MECL1
proteasome subunit beta-2i
NP_038668.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013640.3NP_038668.2  proteasome subunit beta type-10

    See identical proteins and their annotated locations for NP_038668.2

    Status: VALIDATED

    Source sequence(s)
    AC159265, BY686068, D85561
    Consensus CDS
    CCDS22621.1
    UniProtKB/Swiss-Prot
    O35955, Q99KC5
    Related
    ENSMUSP00000034369.9, ENSMUST00000034369.10
    Conserved Domains (3) summary
    TIGR03690
    Location:39238
    20S_bact_beta; proteasome, beta subunit, bacterial type
    cd03763
    Location:40226
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:232267
    Pr_beta_C; Proteasome beta subunits C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106662360..106665024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)