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PSMB10 proteasome 20S subunit beta 10 [ Homo sapiens (human) ]

Gene ID: 5699, updated on 7-Aug-2021

Summary

Official Symbol
PSMB10provided by HGNC
Official Full Name
proteasome 20S subunit beta 10provided by HGNC
Primary source
HGNC:HGNC:9538
See related
Ensembl:ENSG00000205220 MIM:176847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMP10; MECL1; PRAAS5; beta2i
Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 53.2), lymph node (RPKM 48.6) and 25 other tissues See more
Orthologs
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Genomic context

See PSMB10 in Genome Data Viewer
Location:
16q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67934506..67936850, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67968409..67970753, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene neuritin 1 like Neighboring gene protein serine kinase H1 Neighboring gene chymotrypsin like Neighboring gene solute carrier family 12 member 4 Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene dipeptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Proteasome-associated autoinflammatory syndrome 5
MedGen: CN295285 OMIM: 619175 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates LMP7 and MECL1 catalytic subunits of the proteasome resulting in a more efficient generation and presentation of subdominant MHC-I-binding CTL epitopes of heterologous Ags PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
capsid gag HIV-1 CA downregulates PA28beta and the beta2i subunit of the immunoproteasome complex in a dendritic cell line (JAWS II), whereas in primary dendritic cells, PA28alpha, beta2i, and beta5i are downregulated by CA PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CTRL

Homology

Clone Names

  • MGC1665, FLJ00366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex TAS
Traceable Author Statement
more info
PubMed 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of spermatoproteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome subunit beta type-10
Names
low molecular mass protein 10
macropain subunit MECl-1
multicatalytic endopeptidase complex subunit MECl-1
proteasome (prosome, macropain) subunit, beta type, 10
proteasome MECl-1
proteasome catalytic subunit 2i
proteasome subunit MECL1
proteasome subunit beta 10
proteasome subunit beta 7i
proteasome subunit beta-2i
proteasome subunit beta2i
NP_002792.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002801.4NP_002792.1  proteasome subunit beta type-10

    See identical proteins and their annotated locations for NP_002792.1

    Status: REVIEWED

    Source sequence(s)
    BM981173, BP289065
    Consensus CDS
    CCDS10853.1
    UniProtKB/Swiss-Prot
    P40306
    Related
    ENSP00000351314.4, ENST00000358514.9
    Conserved Domains (2) summary
    cd03763
    Location:40227
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:232267
    Pr_beta_C; Proteasome beta subunits C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67934506..67936850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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